State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2054-2058. doi: 10.1002/anie.201611850. Epub 2017 Jan 23.
Asymmetric copper-catalyzed intermolecular amino- and azidocyanation reactions of alkenes have been developed that proceed via a radical process in which a key benzylic radical intermediate is enantioselectively trapped by a chiral Box/Cu cyanide complex. A variety of enantiomerically enriched β-amino/azido alkylnitriles were efficiently synthesized. The β-azido alkylnitriles could be converted into a series of highly valuable optically active amine-based building blocks and bioactive compounds.
发展了一种不对称铜催化的烯烃分子间的氨基和叠氮氰化反应，该反应通过自由基过程进行，其中关键的苄基自由基中间体被手性 Box/Cu 氰化物络合物对映选择性捕获。多种对映体富集的β-氨基/叠氮烷基腈得到高效合成。β-叠氮烷基腈可以转化为一系列高价值的手性基于胺的构建块和生物活性化合物。
