通过可见光诱导 1,7-烯炔与酰氯的级联环化合成稠合吡喃衍生物。
Synthesis of Fused Pyran Derivatives via Visible-Light-Induced Cascade Cyclization of 1,7-Enynes with Acyl Chlorides.
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
出版信息
Org Lett. 2017 Feb 3;19(3):512-515. doi: 10.1021/acs.orglett.6b03684. Epub 2017 Jan 23.
PMID:28111953
Abstract
A photocatalytic cascade cyclization of 1,7-enynes with acyl chlorides has been established. This method offers an operationally simple access to diverse fused pyran derivatives with a broad substrate scope in high yields from simple acyl chlorides via an acyl radical intermediate.
摘要
建立了一种 1,7-烯炔与酰氯的光催化级联环化反应。该方法通过酰基自由基中间体，从简单的酰氯出发，以高收率、较宽的底物范围，操作简便地得到了多种稠合吡喃衍生物。
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