瘦素如何在胰岛素缺乏型糖尿病中恢复正常血糖水平？
How does leptin restore euglycemia in insulin-deficient diabetes?
作者信息
Oberlin Douglas, Buettner Christoph
出版信息
J Clin Invest. 2017 Feb 1;127(2):450-453. doi: 10.1172/JCI91880. Epub 2017 Jan 23.
Abstract
Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.
摘要
胰岛素替代疗法是1型糖尿病（T1D）治疗的基石；然而，血糖控制仍然是一项挑战。在T1D啮齿动物模型中，瘦素已被证明能有效恢复正常血糖水平；然而，瘦素实现血糖控制的具体机制尚不清楚。在本期《临床研究杂志》中，佩里及其同事提供了证据，表明抑制脂肪分解是瘦素介导恢复正常血糖的一个关键方面。然而，要全面了解瘦素的抗糖尿病机制，仍有更多工作要做。
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本文引用的文献
1
Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis.瘦素逆转糖尿病酮症酸中毒的急性非胰岛素依赖效应机制。
J Clin Invest. 2017 Feb 1;127(2):657-669. doi: 10.1172/JCI88477. Epub 2017 Jan 23.
2
Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release.中枢性瘦素恢复1型糖尿病患者的正常血糖水平需要STAT3信号传导，但不需要快速起效的神经递质释放。
Diabetes. 2016 Apr;65(4):1040-9. doi: 10.2337/db15-1160. Epub 2016 Jan 28.
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Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin.反对瘦素抗糖尿病作用中下丘脑-垂体-肾上腺轴受抑制的证据。
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Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia.在未控制的糖尿病中，证据表明高胰高血糖素血症是酮症所必需的，但不是肝葡萄糖生成增加或高血糖所必需的。
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