Faculty of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo, Japan.
TOYOTA MOTOR CORPORATION, 1, Toyota-cho, Toyota, Aichi, Japan.
J Theor Biol. 2018 Nov 7;456:213-223. doi: 10.1016/j.jtbi.2018.08.008. Epub 2018 Aug 8.
Leptin, a hormone released from fat cells in adipose tissues, was recently found to be capable of normalizing glucose metabolism in animals. Clinical data on patients with lipodystrophy indicates that leptin may have a positive effect on glucose metabolism in individuals with diabetes. There are growing expectations that leptin can improve the current insulin treatment for patients with type 1 diabetes. We investigated this possibility through in silico experiments based on a mathematical model of diabetes, which is currently the only mode of research that eliminates human risk. A model of the brain-centered glucoregulatory system, in which leptin plays a central role, was constructed and integrated within a conventional model of insulin/glucose dynamics. The model has been validated using experimental data from animal studies. The in silico combination experiments showed excellent therapeutic performance over insulin monotherapy.
瘦素是一种由脂肪组织中的脂肪细胞分泌的激素，最近发现它能够使动物的葡萄糖代谢正常化。关于脂肪营养不良患者的临床数据表明，瘦素可能对糖尿病患者的葡萄糖代谢有积极影响。人们越来越期望瘦素能够改善目前 1 型糖尿病患者的胰岛素治疗。我们通过基于糖尿病数学模型的计算机模拟实验来研究这种可能性，这是目前唯一消除人类风险的研究模式。构建了一个以瘦素为核心的脑中心糖调节系统模型，并将其整合到胰岛素/葡萄糖动力学的常规模型中。该模型已经使用来自动物研究的实验数据进行了验证。计算机模拟组合实验显示出比胰岛素单一疗法更好的治疗效果。
