Ritskes-Hoitinga J, Lemmens A G, Beynen A C
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
Lab Anim. 1989 Oct;23(4):313-8. doi: 10.1258/002367789780745944.
Nephrocalcinosis is a 'spontaneous' disorder in rats which refers to the deposition of calcium salts in the kidney, preferably in the cortico-medullary region. Studies using defined, semi-purified diets have shown that low dietary concentrations of magnesium, high concentrations of calcium, high concentrations of phosphorus and low calcium: phosphorus ratios induce kidney calcification. Dietary phosphorus induced nephrocalcinosis in female rats is associated with increased kidney size and weight, tubular hyperplasia, fibrosis and increased excretion of albumin in urine. This suggests that nephrocalcinosis may impair kidney function. In rats fed different commercial diets the incidence of nephrocalcinosis can vary considerably. Differences in the degree of nephrocalcinosis in different experiments may negatively influence the comparability of experimental outcome, especially when this is affected by kidney function and structure. Experimental data are needed so that diets can be formulated that do not produce nephrocalcinosis without inducing other disorders.
