Bravo-Soto Gonzalo A, Llovet-Gutiérrez Valentina, Rada Gabriel
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile;
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Medwave. 2017 Jan 16;17(Suppl1):e6834. doi: 10.5867/medwave.2017.6834.
The use of perioperative statins has been proposed as a measure to reduce morbidity and mortality in cardiac surgery. However, their clinical role is controversial. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified 36 systematic reviews comprising 92 primary studies addressing the question of this article, including 22 randomized trials. We extracted data, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded perioperative statins probably do not decrease mortality in cardiac surgery and it is unclear if they have any benefit because the certainty of the evidence is very low.
围手术期使用他汀类药物已被提议作为降低心脏手术发病率和死亡率的一种措施。然而，它们的临床作用存在争议。在通过筛选多个数据库维护的Epistemonikos数据库中进行检索，我们识别出36篇系统评价，其中包含92项针对本文问题的原始研究，包括22项随机试验。我们提取数据，采用荟萃分析合并证据，并按照GRADE方法生成结果总结。我们得出结论，围手术期使用他汀类药物可能不会降低心脏手术的死亡率，而且由于证据的确定性非常低，它们是否有任何益处尚不清楚。
