Department of Medicine, Interfacultary Institute for Microbiology and Infection Medicine (IMIT), University of Tübingen, Elfriede-Aulhorn Straße 6, 72076 Tübingen, Germany.
Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA.
Nat Microbiol. 2017 Jan 23;2:16257. doi: 10.1038/nmicrobiol.2016.257.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are the cause of a severe pandemic consisting primarily of skin and soft tissue infections. The underlying pathomechanisms have not been fully understood and we report here a mechanism that plays an important role for the elevated virulence of CA-MRSA. Surprisingly, skin abscess induction in an animal model was correlated with the amount of a major cell wall component of S. aureus, termed wall teichoic acid (WTA). CA-MRSA exhibited increased cell-wall-associated WTA content (WTA) and thus were more active in inducing abscess formation via a WTA-dependent and T-cell-mediated mechanism than S. aureus strains with a WTA phenotype. We show here that WTA is directly involved in S. aureus strain-specific virulence and provide insight into the underlying molecular mechanisms that could guide the development of novel anti-infective strategies.
社区相关性耐甲氧西林金黄色葡萄球菌（CA-MRSA）是一种严重的大流行的原因，主要由皮肤和软组织感染。潜在的发病机制尚未完全理解，我们在这里报告了一个机制，在 CA-MRSA 的毒力升高中起着重要作用。令人惊讶的是，动物模型中的皮肤脓肿诱导与金黄色葡萄球菌的一种主要细胞壁成分的量有关，称为壁磷壁酸（WTA）。CA-MRSA 表现出增加的细胞壁相关 WTA 含量（WTA），因此通过 WTA 依赖性和 T 细胞介导的机制比 WTA 表型的金黄色葡萄球菌菌株更活跃地诱导脓肿形成。我们在这里表明，WTA 直接参与金黄色葡萄球菌菌株特异性毒力，并深入了解潜在的分子机制，这可能指导新的抗感染策略的发展。
