抗炎药物美沙拉嗪针对细菌多聚磷酸盐的积累。
The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation.
机构信息
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
Nat Microbiol. 2017 Jan 23;2:16267. doi: 10.1038/nmicrobiol.2016.267.
Abstract
Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria towards oxidative stress, reduces colonization and attenuates persister cell and biofilm formation, suggesting that mesalamine aids in diminishing the capacity of bacteria to persist within chronically inflamed environments.
摘要
美沙拉嗪是治疗溃疡性结肠炎的金标准。然而，其确切的作用机制尚不清楚。在这里，我们表明美沙拉嗪治疗可迅速降低多种细菌（包括人类肠道微生物组的成员）中的多磷酸盐水平。这种减少使细菌对氧化应激敏感，减少定植并减弱持久细胞和生物膜的形成，表明美沙拉嗪有助于减少细菌在慢性炎症环境中持续存在的能力。
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