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What dose of 5-aminosalicylic acid (mesalazine) in ulcerative colitis?

作者信息

Riley S A

机构信息

Department of Gastroenterology, Northern General Hospital, Sheffield, UK.

出版信息

Gut. 1998 Jun;42(6):761-3. doi: 10.1136/gut.42.6.761.

DOI:10.1136/gut.42.6.761
PMID:9691909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1727139/
Abstract
摘要

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What dose of 5-aminosalicylic acid (mesalazine) in ulcerative colitis?溃疡性结肠炎中5-氨基水杨酸（美沙拉嗪）的剂量是多少？
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Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.5-氨基水杨酸的肠道抗炎作用依赖于过氧化物酶体增殖物激活受体γ。
J Exp Med. 2005 Apr 18;201(8):1205-15. doi: 10.1084/jem.20041948. Epub 2005 Apr 11.
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Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine.使用益生菌大肠杆菌Nissle 1917维持溃疡性结肠炎缓解的效果与使用标准美沙拉嗪相当。
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Gut. 2001 Dec;49(6):783-9. doi: 10.1136/gut.49.6.783.

本文引用的文献

1
A critical analysis of the use of salicylazosulfapyridine in chronic ulcerative colitis.柳氮磺胺吡啶在慢性溃疡性结肠炎中的应用批判性分析。
Ann Intern Med. 1959 Nov;51:879-89. doi: 10.7326/0003-4819-51-5-879.
2
CONTROLLED TRIAL OF SULPHASALAZINE IN THE TREATMENT OF ULCERATIVE COLITIS.柳氮磺胺吡啶治疗溃疡性结肠炎的对照试验
Gut. 1964 Oct;5(5):437-42. doi: 10.1136/gut.5.5.437.
3
Sulphasalazine and salicylazosulphadimidine in ulcerative colitis.柳氮磺胺吡啶和水杨酸偶氮磺胺嘧啶治疗溃疡性结肠炎
Lancet. 1962 May 26;1(7239):1094-6. doi: 10.1016/s0140-6736(62)92080-9.
4
Balsalazide is more effective and better tolerated than mesalamine in the treatment of acute ulcerative colitis. The Abacus Investigator Group.在治疗急性溃疡性结肠炎方面，巴柳氮比美沙拉嗪更有效且耐受性更好。算盘研究组。
Gastroenterology. 1998 Jan;114(1):15-22. doi: 10.1016/s0016-5085(98)70627-4.
5
A double-blind comparison of oral versus rectal mesalamine versus combination therapy in the treatment of distal ulcerative colitis.口服美沙拉嗪与直肠用美沙拉嗪及联合治疗远端溃疡性结肠炎的双盲对照研究
Am J Gastroenterol. 1997 Oct;92(10):1867-71.
6
Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis.溃疡性结肠炎中直肠用皮质类固醇与替代疗法的比较：一项荟萃分析。
Gut. 1997 Jun;40(6):775-81. doi: 10.1136/gut.40.6.775.
7
Renal tubular dysfunction in patients with inflammatory bowel disease treated with aminosalicylate.接受氨基水杨酸盐治疗的炎症性肠病患者的肾小管功能障碍
Gut. 1997 Jun;40(6):761-6. doi: 10.1136/gut.40.6.761.
8
Combined therapy with 5-aminosalicylic acid tablets and enemas for maintaining remission in ulcerative colitis: a randomized double-blind study.5-氨基水杨酸片剂与灌肠剂联合治疗维持溃疡性结肠炎缓解：一项随机双盲研究。
Am J Gastroenterol. 1997 Jul;92(7):1143-7.
9
Comparison of the efficacy and safety of 1.5 compared with 3.0 g oral slow-release mesalazine (Pentasa) in the maintenance treatment of ulcerative colitis. Dutch Pentasa Study Group.1.5克与3.0克口服缓释美沙拉嗪（颇得斯安）用于溃疡性结肠炎维持治疗的疗效与安全性比较。荷兰颇得斯安研究组
Eur J Gastroenterol Hepatol. 1995 Nov;7(11):1025-30. doi: 10.1097/00042737-199511000-00003.
10
Intermittent therapy with high-dose 5-aminosalicylic acid enemas maintains remission in ulcerative proctitis and proctosigmoiditis.高剂量5-氨基水杨酸灌肠剂间歇性治疗可维持溃疡性直肠炎和直肠乙状结肠炎的缓解。
Dis Colon Rectum. 1994 Jan;37(1):58-62. doi: 10.1007/BF02047216.