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Obesity As a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: Methodologic Issues to Avoid Misinterpretation in the Meta-Analysis.

作者信息

Cheraghi Zahra, Ayubi Erfan, Doosti-Irani Amin

机构信息

Zahra Cheraghi, Hamadan University of Medical Sciences, Hamadan, Iran; Erfan Ayubi, Shahid Beheshti University of Medical Sciences and Tehran University of Medical Sciences, Tehran, Iran; and Amin Doosti-Irani, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Clin Oncol. 2017 Mar 10;35(8):923. doi: 10.1200/JCO.2016.71.0715. Epub 2017 Jan 23.

DOI:10.1200/JCO.2016.71.0715
PMID:28113010
Abstract
摘要

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Obesity As a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: Methodologic Issues to Avoid Misinterpretation in the Meta-Analysis.肥胖作为乳腺癌中蒽环类药物和曲妥珠单抗心脏毒性的危险因素：在荟萃分析中避免错误解读的方法学问题
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Implications of excess weight in the cardiotoxicity of anthracyclines and trastuzumab in breast cancer.超重对蒽环类药物和曲妥珠单抗在乳腺癌中所致心脏毒性的影响。
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[Overweight and obesity are risk factors for development of cardiotoxicity from anthracyclines or sequential administration of anthracyclines and trastuzumab].超重和肥胖是蒽环类药物或蒽环类药物与曲妥珠单抗序贯给药导致心脏毒性的危险因素。
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SAFE trial: an ongoing randomized clinical study to assess the role of cardiotoxicity prevention in breast cancer patients treated with anthracyclines with or without trastuzumab.SAFE试验：一项正在进行的随机临床研究，旨在评估在接受蒽环类药物治疗（无论是否联合曲妥珠单抗）的乳腺癌患者中预防心脏毒性的作用。
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Reply to Z. Cheraghi et al.对Z. 切拉吉等人的回复
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Factors predicting trastuzumab-related cardiotoxicity in a real-world population of women with HER2+ breast cancer.曲妥珠单抗相关心脏毒性的预测因素：HER2+乳腺癌女性真实世界人群的研究。
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Risk of severe cardiotoxicity following treatment with trastuzumab: a meta-analysis of randomized and cohort studies of 29,000 women with breast cancer.曲妥珠单抗治疗后严重心脏毒性的风险：对 29000 名乳腺癌女性的随机和队列研究的荟萃分析。
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