Hover Samantha, Foster Becky, Barr John N, Mankouri Jamel
School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
J Gen Virol. 2017 Mar;98(3):345-351. doi: 10.1099/jgv.0.000712. Epub 2017 Apr 1.
The broad range of cellular functions governed by ion channels represents an attractive target for viral manipulation. Indeed, modulation of host cell ion channel activity by viral proteins is being increasingly identified as an important virus-host interaction. Recent examples have demonstrated that virion entry, virus egress and the maintenance of a cellular environment conducive to virus persistence are, in part, dependent on virus manipulation of ion channel activity. Most excitingly, evidence has emerged that targeting ion channels pharmacologically can impede virus life cycles. Here, we discuss current examples of virus-ion channel interactions and the potential of targeting ion channel function as a new, pharmacologically safe and broad-ranging anti-viral therapeutic strategy.
离子通道所调控的广泛细胞功能是病毒操控的一个有吸引力的靶点。事实上，病毒蛋白对宿主细胞离子通道活性的调节日益被视为一种重要的病毒-宿主相互作用。最近的实例表明，病毒粒子的进入、病毒释放以及维持有利于病毒持续存在的细胞环境，部分依赖于病毒对离子通道活性的操控。最令人兴奋的是，有证据表明，通过药物靶向离子通道可阻碍病毒生命周期。在此，我们讨论病毒与离子通道相互作用的当前实例，以及将靶向离子通道功能作为一种新的、具有药理学安全性且适用范围广泛的抗病毒治疗策略的潜力。
