Malekolkottab Masoume, Khalili Hossein, Mohammadi Mostafa, Ramezani Masoud, Nourian Anahid
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Intensive Care Unit, Imam Khomeini Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Comp Eff Res. 2017 Mar;6(2):127-136. doi: 10.2217/cer-2016-0067. Epub 2017 Jan 24.
Metoclopramide is commonly used as a prokinetic agent in critically ill patients with enteral feeding intolerance. In this study, noninferiority of metoclopramide as intermittent versus continuous infusion was examined in critically ill patients with enteral feeding intolerance.
Forty critically ill adults patients were assigned to receive metoclopramide as either intermittent (10 mg every 6 h) or continuous (2 mg/h) infusion. Frequency of feeding intolerance and adverse effects of metoclopramide were assessed during 7 days of study.
Number of patients with feeding intolerance during different times of the course was not different between the groups. Although not statistically significant, diarrhea and cardiac rhythm were more common in continuous than intermittent infusion group.
Continuous and intermittent infusions of metoclopramide showed equivalent effectiveness in critically ill patients.
甲氧氯普胺常用于伴有肠内营养不耐受的重症患者，作为促动力药物。本研究在伴有肠内营养不耐受的重症患者中，检验了甲氧氯普胺间歇性输注与持续输注的非劣效性。
40例成年重症患者被分配接受甲氧氯普胺间歇性输注（每6小时10毫克）或持续输注（每小时2毫克）。在7天的研究期间评估营养不耐受的频率和甲氧氯普胺的不良反应。
两组在病程不同时间点出现营养不耐受的患者数量无差异。虽然无统计学意义，但持续输注组腹泻和心律失常比间歇性输注组更常见。
在重症患者中，甲氧氯普胺持续输注和间歇性输注显示出等效疗效。
