Kinnon C, Katz F
Department of Immunology, Institute of Child Health, London, U.K.
Leukemia. 1989 Nov;3(11):808-12.
Immunoglobulin and T cell receptor gene rearrangement and expression were investigated within B cell acute lymphoblastic leukemias (ALLs) that are thought to be representative of the early stages of normal human B cell development. Although the immunoglobulin heavy chain locus is rearranged in leukemic cells from all of these patients, only cells from pre-B ALL patients express mu chain protein. We have shown, however, that immunoglobulin heavy chain transcripts are expressed at levels similar to those found in normal B cells in all of these leukemic cell types and, in addition, some of the leukemias with a more mature phenotype also express immunoglobulin light chain mRNA. In contrast, leukemic cells which had rearranged T cell receptor gamma chain genes were not found to express gamma chain transcripts, indicating that the transcription of immunoglobulin and T cell receptor genes in these cells may be regulated in a lineage-specific manner.
在被认为代表正常人B细胞发育早期阶段的B细胞急性淋巴细胞白血病（ALL）中，研究了免疫球蛋白和T细胞受体基因的重排与表达。尽管所有这些患者的白血病细胞中免疫球蛋白重链基因座都发生了重排，但只有前B-ALL患者的细胞表达μ链蛋白。然而，我们已经表明，在所有这些白血病细胞类型中，免疫球蛋白重链转录本的表达水平与正常B细胞中的表达水平相似，此外，一些具有更成熟表型的白血病也表达免疫球蛋白轻链mRNA。相比之下，未发现重排了T细胞受体γ链基因的白血病细胞表达γ链转录本，这表明这些细胞中免疫球蛋白和T细胞受体基因的转录可能以谱系特异性方式受到调控。
