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B前体白血病中T细胞受体α链基因重排与T细胞急性淋巴细胞白血病的研究结果形成对比。儿童白血病中T细胞受体基因重排的比较研究。

T cell receptor alpha-chain gene rearrangements in B-precursor leukemia are in contrast to the findings in T cell acute lymphoblastic leukemia. Comparative study of T cell receptor gene rearrangement in childhood leukemia.

作者信息

Hara J, Benedict S H, Mak T W, Gelfand E W

机构信息

Division of Immunology and Rheumatology, Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

J Clin Invest. 1987 Dec;80(6):1770-7. doi: 10.1172/JCI113270.

DOI:10.1172/JCI113270
PMID:3500187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC442452/
Abstract

We have analyzed T cell receptor alpha-chain gene configuration using three genomic joining (J) region probes in 64 children with acute lymphoblastic leukemia (ALL). 11 out of 18 T-ALLs were T3 positive; alpha-chain gene rearrangements were demonstrated in only two of 18, indicating that the majority of T-ALLs would have rearrangements involving J alpha segments located upstream of these probes. In contrast, 15 out of 46 B-precursor ALLs showed rearrangements of the alpha-chain gene and J alpha segments located approximately 20-30 kb upstream of the constant region were involved in 13 of these patients. Nine of 15 B-precursor ALLs with rearranged alpha-chain genes had rearrangements of both gamma- and beta-chain genes, whereas the remaining six had no rearrangements of gamma- and beta-chain genes. These findings indicated that alpha-chain gene rearrangement is not specific for T lineage cells and gamma- and/or beta-chain gene rearrangement does not appear essential for alpha-chain gene rearrangement, at least in B-precursor leukemic cells.

摘要

我们使用三种基因组连接（J）区探针，对64例急性淋巴细胞白血病（ALL）患儿的T细胞受体α链基因构型进行了分析。18例T-ALL中有11例T3呈阳性；18例中仅2例显示α链基因重排，这表明大多数T-ALL会发生涉及这些探针上游Jα片段的重排。相比之下，46例B前体ALL中有15例显示α链基因重排，其中13例患者涉及位于恒定区上游约20 - 30 kb处的Jα片段。15例α链基因重排的B前体ALL中，9例γ链和β链基因均发生重排，而其余6例γ链和β链基因未发生重排。这些发现表明，α链基因重排并非T系细胞所特有，并且γ链和/或β链基因重排对于α链基因重排似乎并非必不可少，至少在B前体白血病细胞中是如此。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/e5f472503863/jcinvest00096-0267-m.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/01a5fc3dfad4/jcinvest00096-0267-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/f877323d862f/jcinvest00096-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/fdbc7d4a2e53/jcinvest00096-0266-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/142d494e4063/jcinvest00096-0267-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/01a5fc3dfad4/jcinvest00096-0267-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/6ec6abefde6d/jcinvest00096-0267-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/fe225b8a91e1/jcinvest00096-0267-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/2c0c7131fe2f/jcinvest00096-0267-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/a5454c77eca5/jcinvest00096-0267-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/bcd77cbb58f2/jcinvest00096-0267-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/59f3aab581f6/jcinvest00096-0267-h.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6401/442452/408b8215dc94/jcinvest00096-0267-i.jpg
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本文引用的文献

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Br J Haematol. 1981 Jun;48(2):179-97.
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Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.人类胸腺内分化的离散阶段：T细胞系正常胸腺细胞和白血病淋巴母细胞的分析
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588-92. doi: 10.1073/pnas.77.3.1588.
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Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences.
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