Venero J L, Machado A, Cano J
Departmento de Bioquimica, Facultad de Farmacia, Sevilla, Spain.
Mech Ageing Dev. 1989 Sep;49(3):227-33. doi: 10.1016/0047-6374(89)90073-0.
A decrease in the monoamine and monoamine metabolite contents in the substantia nigra of aged rats vs. controls has been found. Hence, it can be speculated that this decrease may play a role in the multiple alterations in dopaminergic functions observed in aged rats.