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肌腱断裂及延迟修复后肌肉活动度变化与胶原蛋白含量之间的相关性。

Correlation between change in muscle excursion and collagen content after tendon rupture and delayed repair.

作者信息

Koh Il-Hyun, Kang Ho-Jung, Oh Won-Taek, Hong Jung-Jun, Choi Yun-Rak

机构信息

Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.

出版信息

J Orthop Surg Res. 2017 Jan 23;12(1):15. doi: 10.1186/s13018-017-0518-y.

DOI:10.1186/s13018-017-0518-y
PMID:28115019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5260042/
Abstract

BACKGROUND

The objectives of the present study were to compare changes in muscle excursion, total collagen, and collagen subtypes after tenotomy over time and after delayed tendon repair.

METHODS

Tenotomy on the extensor digitorum tendon of the right second toes of 48 New Zealand White rabbits was performed; toes on the left leg were used as controls. Passive muscle excursion, total collagen content, and type I, III, and IV collagen contents were measured at 1, 2, 4, and 6 weeks after tenotomy. Next, passive muscle excursion and total collagen content were measured at 8 weeks after delayed tendon repair at 1, 2, 4, and 6 weeks after a tenotomy.

RESULTS

Passive muscle excursion decreased sequentially over time after tenotomy. Meanwhile, total collagen increased over time. These changes were significant after 4 weeks of injury. Type I collagen significantly increased, type III collagen significantly decreased, and type IV collagen had no significant change over time. Passive muscle excursion was negatively correlated with total collagen and type I collagen after tenotomy at each time point after tenotomy (p < 0.05). After tendon repair, increases in total collagen content after tenotomy were not reversed, despite early repairs at 1 and 2 weeks after tenotomy.

CONCLUSIONS

Increases in type I collagen were found to be associated with decreased excursion after tendon rupture. The increase in collagen that was observed after tenotomy was not reversed by repair within 8 weeks.

摘要

背景

本研究的目的是比较腱切断术后随时间推移以及延迟肌腱修复后肌肉 excursion、总胶原蛋白和胶原蛋白亚型的变化。

方法

对 48 只新西兰白兔右第二趾的趾长伸肌腱进行腱切断术；以左腿的趾作为对照。在腱切断术后 1、2、4 和 6 周测量被动肌肉 excursion、总胶原蛋白含量以及 I、III 和 IV 型胶原蛋白含量。接下来，在腱切断术后 1、2、4 和 6 周进行延迟肌腱修复，在修复后 8 周测量被动肌肉 excursion 和总胶原蛋白含量。

结果

腱切断术后，被动肌肉 excursion 随时间依次降低。同时，总胶原蛋白随时间增加。损伤 4 周后这些变化显著。I 型胶原蛋白显著增加，III 型胶原蛋白显著降低，IV 型胶原蛋白随时间无显著变化。腱切断术后每个时间点，被动肌肉 excursion 与总胶原蛋白和 I 型胶原蛋白呈负相关（p < 0.05）。肌腱修复后，尽管在腱切断术后 1 和 2 周进行了早期修复，但腱切断术后总胶原蛋白含量的增加并未逆转。

结论

发现 I 型胶原蛋白增加与肌腱断裂后 excursion 降低有关。腱切断术后观察到的胶原蛋白增加在 8 周内未因修复而逆转。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/d1b9ad795cc3/13018_2017_518_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/9a0c587b6f8e/13018_2017_518_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/6440875e385d/13018_2017_518_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/394eb96a1677/13018_2017_518_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/d1b9ad795cc3/13018_2017_518_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/9a0c587b6f8e/13018_2017_518_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/6440875e385d/13018_2017_518_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/394eb96a1677/13018_2017_518_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b6/5260042/d1b9ad795cc3/13018_2017_518_Fig4_HTML.jpg

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