Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States.
Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States.
Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt B):2564-2573. doi: 10.1016/j.bbadis.2017.01.013. Epub 2017 Jan 20.
Early host recognition of microbial invasion or damaged host tissues provides an effective warning system by which protective immune and inflammatory processes are initiated. Host tissues responsible for continuous sampling of their local environment employ cell surface and cytosolic pattern recognition receptors (PRRs) that provide redundant and overlapping identification of both microbial and host alarmins. Microbial products containing pathogen-associated molecular patterns (PAMPs), as well as damage-associated molecular patterns (DAMPs) serve as principle ligands for recognition by these PRRs. It is this interaction which plays both an essential survival role in response to infection and injury, as well as the pathologic role in tissue and organ injury associated with severe sepsis and trauma. Elucidating the interaction between ligands and their respective PRRs can provide both a better understanding of the host response, as well as a rational basis for therapeutic intervention. This article is part of a Special Issue entitled: Immune and Metabolic Alterations in Trauma and Sepsis edited by Dr. Raghavan Raju.
早期宿主对微生物入侵或受损宿主组织的识别提供了一个有效的预警系统，通过该系统启动了保护性免疫和炎症过程。负责持续采样其局部环境的宿主组织利用细胞表面和细胞溶质模式识别受体（PRRs），对微生物和宿主警报素进行冗余和重叠的识别。含有病原体相关分子模式（PAMPs）以及损伤相关分子模式（DAMPs）的微生物产物作为这些 PRRs 识别的主要配体。正是这种相互作用，在应对感染和损伤时发挥了至关重要的生存作用，以及在严重脓毒症和创伤相关的组织和器官损伤中发挥了病理作用。阐明配体与其各自 PRRs 之间的相互作用，可以更好地了解宿主的反应，以及为治疗干预提供合理的依据。本文是由 Raghavan Raju 博士主编的题为“创伤和败血症中的免疫和代谢改变”的特刊的一部分。
