血小板因子4与血管蛋白聚糖结合，并控制生长因子活性和血小板活化。
Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation.
作者信息
Lord Megan S, Cheng Bill, Farrugia Brooke L, McCarthy Simon, Whitelock John M
机构信息
From the Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia and
From the Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia and.
出版信息
J Biol Chem. 2017 Mar 10;292(10):4054-4063. doi: 10.1074/jbc.M116.760660. Epub 2017 Jan 23.
Abstract
Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound healing. PF4 is stored in platelet α-granules bound to the glycosaminoglycan (GAG) chains of serglycin. This study revealed that platelet serglycin is decorated with chondroitin/dermatan sulfate and that PF4 binds to these GAG chains. Additionally, PF4 had a higher affinity for endothelial-derived perlecan heparan sulfate chains than serglycin GAG chains. The binding of PF4 to perlecan was found to inhibit both FGF2 signaling and platelet activation. This study revealed additional insight into the ways in which PF4 interacts with components of the vasculature to modulate cellular events.
摘要
血小板因子4（PF4）由血小板产生，在炎症和伤口愈合中均发挥作用。PF4存储于血小板α颗粒中，与丝甘蛋白聚糖的糖胺聚糖（GAG）链结合。本研究表明，血小板丝甘蛋白聚糖带有硫酸软骨素/硫酸皮肤素修饰，且PF4可与这些GAG链结合。此外，PF4对内皮细胞源的基底膜聚糖硫酸乙酰肝素链的亲和力高于丝甘蛋白聚糖GAG链。研究发现，PF4与基底膜聚糖的结合可抑制FGF2信号传导和血小板活化。本研究进一步揭示了PF4与脉管系统成分相互作用以调节细胞事件的方式。
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J Biol Chem. 2017 Mar 10;292(10):4054-4063. doi: 10.1074/jbc.M116.760660. Epub 2017 Jan 23.
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