Oberhuber G, Pointner R, Lauer E, Waldenberger P, Radaszkiewicz T
Anatomische Pathologie, Universität Innsbruck.
Leber Magen Darm. 1989 Sep;19(5):270-4.
We report on a 42 year old male patient having been ill with pseudo-pobstruction and gastroinstestinal atonid for 24 years. He was thought to suffer from Crohn's disease and was treated conservatively. Since the therapy proved to be insufficient, explorative laparatomie was performed and parts of the small and large intestine which were thought to be inflamed, were removed. The histologic examination revealed the deposition of a significant amount of lipofuscin in the muscularis propria. This so-called brown bowel syndrome is known to be responsible for the development of gastrointestinal atonia. It is generally believed that this syndrome is caused by a vitamin E deficiency which may occur due to malabsorption. The brown bowel syndrome is treated sympomatically, and until now only one case achieving a remission of the disease has been reported.
我们报告了一名42岁男性患者，他患有假性肠梗阻和胃肠道无力24年。他曾被认为患有克罗恩病并接受了保守治疗。由于治疗效果不佳，遂进行了探查性剖腹手术，切除了被认为发炎的部分小肠和大肠。组织学检查显示固有肌层中有大量脂褐素沉积。这种所谓的棕色肠综合征被认为是胃肠道无力发展的原因。一般认为，这种综合征是由维生素E缺乏引起的，而维生素E缺乏可能是由于吸收不良所致。棕色肠综合征采用对症治疗，到目前为止，仅报道过一例疾病缓解的病例。
