Çelik Güner, Doğan Ali, Dener Şefik, Öztürk Şerefnur, Kulaksızoğlu Sevsen, Ekmekçi Hakan
Beyhekim State Hospital, Department of Neurology, Konya, Turkey.
Bandırma State Hospital, Department of Neurology, Balıkesir, Turkey.
Dis Markers. 2017;2017:4343171. doi: 10.1155/2017/4343171. Epub 2017 Jan 2.
. It was examined whether PTH and 25-dihydroxyvitamin D (25(OH)D) levels, together or separately, are indicators of the risk of stroke. . This prospective study was performed at two centers. In the study, 100 patients diagnosed with acute ischemic stroke and 100 control individuals in the same age range were examined. In addition to neurological examination, cranial imaging, extensive routine blood chemistry, PTH, and 25(OH)D levels were evaluated in all cases. Stroke risk factors were determined. Logistic regression was used for statistical analysis. . A total of 60 patients and 79 control individuals were included in the study. Different estimation models were designed in order to examine the relationship between PTH and 25(OH)D levels with stroke. According to modeling results, it was determined that the most effective predictor for risk of stroke was 25(OH)D levels, followed by hypertension and PTH levels, respectively. . PTH and 25(OH)D levels together can make important contributions to determination of stroke risk, and further investigations are needed to understand this relationship more fully.
研究了甲状旁腺激素（PTH）和25-二羟基维生素D（25(OH)D）水平单独或共同作为中风风险指标的情况。本前瞻性研究在两个中心进行。研究中，对100例诊断为急性缺血性中风的患者和100例年龄范围相同的对照个体进行了检查。除神经学检查、头颅成像外，还对所有病例进行了广泛的常规血液生化、PTH和25(OH)D水平评估。确定了中风危险因素。采用逻辑回归进行统计分析。共有60例患者和79例对照个体纳入研究。为研究PTH和25(OH)D水平与中风之间的关系设计了不同的评估模型。根据建模结果，确定中风风险最有效的预测指标是25(OH)D水平，其次分别是高血压和PTH水平。PTH和25(OH)D水平共同可为中风风险的判定做出重要贡献，需要进一步研究以更全面地了解这种关系。
