Altay Hakan, Altın Cihan, Coner Ali, Muderrisoglu Haldun, Giray Semih
Department of Cardiology, Faculty of Medicine, Baskent University, Ankara, Turkey.
Neurology, Faculty of Medicine, Baskent University, Ankara, Turkey.
Endocr Metab Immune Disord Drug Targets. 2019;19(8):1134-1140. doi: 10.2174/1871530319666190215150410.
Increased parathyroid hormone (PTH) level is associated with coronary artery disease, hypertension and left ventricular hypertrophy which are all predisposing factors for the ischemic cerebrovascular event (ICVE). Carotid intima-media thickness (CIMT) and aortic distensibility are the two early, subclinical predictors of atherosclerosis. The relation of PTH with CIMT and aortic distensibility in patients with ICVE has not been previously studied.
Our aim was to study the relationship of PTH levels with aortic distensibility and CIMT in patients with ICVE.
Sixty-four ICVE patients and 50 control group were enrolled in the study. PTH levels, aortic distensibility and CIMT were measured in all individuals.
PTH levels were significantly higher in ICVE patients than in the controls (60.1±21.6 vs. 52.3±6.2 pg/ml) (p=0. 008). PTH levels were found to be inversely correlated with aortic distensibility (r= -0. 420, p=0.001) and positively correlated with CIMT (r:0, 285, p=0,002).
The present study shows that PTH levels are increased in patients with acute ischemic cerebrovascular event compared to the control group. It also demonstrates that PTH levels are inversely related to aortic distensibility of ascending aorta and positively associated with CIMT.
甲状旁腺激素（PTH）水平升高与冠状动脉疾病、高血压和左心室肥厚相关，而这些都是缺血性脑血管事件（ICVE）的诱发因素。颈动脉内膜中层厚度（CIMT）和主动脉扩张性是动脉粥样硬化的两个早期亚临床预测指标。此前尚未研究过ICVE患者中PTH与CIMT及主动脉扩张性之间的关系。
我们的目的是研究ICVE患者中PTH水平与主动脉扩张性及CIMT之间的关系。
本研究纳入了64例ICVE患者和50例对照组。测量了所有个体的PTH水平、主动脉扩张性和CIMT。
ICVE患者的PTH水平显著高于对照组（60.1±21.6 vs. 52.3±6.2 pg/ml）（p = 0.008）。发现PTH水平与主动脉扩张性呈负相关（r = -0.420，p = 0.001），与CIMT呈正相关（r = 0.285，p = 0.002）。
本研究表明，与对照组相比，急性缺血性脑血管事件患者的PTH水平升高。研究还表明，PTH水平与升主动脉的主动脉扩张性呈负相关，与CIMT呈正相关。
