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J Blood Med. 2016 Dec 30;8:1-4. doi: 10.2147/JBM.S96465. eCollection 2017.
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7
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N Engl J Med. 1994 Mar 24;330(12):827-38. doi: 10.1056/NEJM199403243301206.

无关供者外周造血干细胞采集前精神并发症的管理。

Management of psychiatric complications in unrelated donor before unrelated peripheral hematopoietic stem cell collections.

作者信息

Hequet Olivier, Mialou Valerie, Audat Francoise, Wattel Eric, Chapel Valerie, Revesz Damiela, Jouet Jean-Piere, Fisseaux Brigitte, Saoud Mohamed, Michallet Mauricette

机构信息

Apheresis Unit; Cell Therapy Laboratory, Etablissement Français du Sang (EFS) Rhône Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite.

Cell Therapy Laboratory, Etablissement Français du Sang (EFS) Rhône Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite.

出版信息

J Blood Med. 2016 Dec 30;8:1-4. doi: 10.2147/JBM.S96465. eCollection 2017.

DOI:10.2147/JBM.S96465
PMID:28115876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5221806/
Abstract

Allogeneic hematopoietic stem cell transplantation can efficiently treat patients with severe hematological diseases. A human leukocyte antigen-compatible donor is required for performing transplantation. The occurrence of unexpected acute severe diseases in a donor can compromise the feasibility of allogeneic hematopoietic stem cell transplantation. However, when a severe health problem occurs in a donor while the recipient has already received a conditioning regimen, hematologists have to find the best solutions for the recipient, while the team in charge of the donor has to find the best medical solutions for the donor. We describe here the occurrence of psychiatric acute complications in an unrelated donor while the myeloablative conditioning regimen had already been given to the recipient. We report the successive decisions that were made in an emergency based upon the expertise of physicians specialized in hematology, apheresis, cell therapy, and psychiatry to preserve the donor's health and recipient's life.

摘要

异基因造血干细胞移植能够有效治疗严重血液疾病患者。进行移植需要人类白细胞抗原匹配的供者。供者意外发生急性重症疾病可能会影响异基因造血干细胞移植的可行性。然而，当供者出现严重健康问题而受者已经接受了预处理方案时，血液科医生必须为受者寻找最佳解决方案，而负责供者的团队则必须为供者寻找最佳医疗方案。我们在此描述了一名无关供者在受者已经接受清髓性预处理方案时发生精神科急性并发症的情况。我们报告了基于血液学、单采术、细胞治疗和精神病学专家的专业知识在紧急情况下做出的一系列决策，以维护供者的健康和受者的生命。