Horowitz Mary M, Confer Dennis L
Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Hematology Am Soc Hematol Educ Program. 2005:469-75. doi: 10.1182/asheducation-2005.1.469.
Donation of hematopoietic stem cells, either through bone marrow or peripheral blood collection, is a generally safe procedure for healthy donors. Serious adverse events are uncommon and death is exceedingly rare. Nevertheless, all donors must be carefully evaluated and fully informed prior to donation. This should be done by clinicians having good understanding of the potential physical and psychological complications of donation and the factors that may increase these risks. Additionally, donors and graft products must be evaluated for the potential to transmit infections and other diseases to the recipient and to satisfy an increasing number of national and international regulatory requirements. Donors must be able to provide informed consent without coercion or pressure. Special attention to the clinical, psychological and social needs of pediatric donors is necessary.
通过骨髓或外周血采集进行造血干细胞捐献，对于健康捐献者来说通常是一种安全的程序。严重不良事件并不常见，死亡极为罕见。然而，所有捐献者在捐献前都必须经过仔细评估并充分了解相关情况。这应由对捐献潜在的身体和心理并发症以及可能增加这些风险的因素有充分了解的临床医生来进行。此外，必须对捐献者和移植物产品进行评估，以确定其向受者传播感染和其他疾病的可能性，并满足越来越多的国家和国际监管要求。捐献者必须能够在没有强迫或压力的情况下提供知情同意。有必要特别关注儿科捐献者的临床、心理和社会需求。
