微小RNA在胆管癌中的新兴作用及其临床意义
The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer.
作者信息
Ferreira Martins Nina Nayara, da Silva Oliveira Kelly Cristina, Braga Bona Amanda, de Arruda Cardoso Smith Marília, Ishak Geraldo, Assumpção Paulo Pimentel, Burbano Rommel Rodríguez, Calcagno Danielle Queiroz
机构信息
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, Brazil.
Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.
出版信息
Gastroenterol Res Pract. 2016;2016:9797410. doi: 10.1155/2016/9797410. Epub 2016 Dec 27.
Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several single-nucleotide polymorphisms in genes that are associated with the susceptibility of biliary tract tumors.
胆道癌是侵袭性恶性肿瘤，包括胆囊癌以及肝内和肝外胆管肿瘤，预后较差。手术切除仍然是主要的治愈性疗法。然而，许多患者即使在根治性手术后仍会复发。这种情况推动了对胆道癌生物标志物的研究，尽管进展有限。最近，大量研究表明，微小RNA的表达失调与癌症的发生和发展密切相关。在本综述中，我们重点介绍了微小RNA在胆道癌中的作用和重要性，强调将循环微小RNA作为潜在生物标志物的应用。此外，我们报告了与胆道肿瘤易感性相关基因中的几个单核苷酸多态性。
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