微小RNA在胆囊癌中的作用。
The role of microRNAs in gallbladder cancer.
作者信息
Yang Ganghua, Zhang Lei, Li Ruixiang, Wang Lin
机构信息
Department of Geriatric Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
出版信息
Mol Clin Oncol. 2016 Jul;5(1):7-13. doi: 10.3892/mco.2016.905. Epub 2016 May 11.
Abstract
MicroRNAs (also referred to as miRNAs or miRs) play a crucial role in post-transcriptional gene regulation and serve as negative gene regulators by controlling a variety of target genes and regulating diverse biological processes, such as cell proliferation, invasion, migration and apoptosis. Aberrant expression of miRNAs is associated with the development and progression of cancer. Recent studies have reported that miRNAs may repress or promote the expression of cancer-related genes via several different signaling pathways in gallbladder cancer (GBC) patients and may function as tumor suppressors or oncogenes, thus providing a promising tool for the diagnosis and therapeutics of GBCs. In this review, we summarize the role of dysregulawted miRNA expression in the signaling pathways implicated in GBC and discuss the significant role of circulating miRNAs in GBC. Therefore, miRNAs may serve as novel therapeutic targets as well as diagnostic or prognostic markers in GBC.
摘要
微小RNA（也称为miRNA或miR）在转录后基因调控中发挥关键作用，并通过控制多种靶基因和调节多种生物学过程（如细胞增殖、侵袭、迁移和凋亡）作为负性基因调节因子。微小RNA的异常表达与癌症的发生和发展相关。最近的研究报道，微小RNA可能通过几种不同的信号通路抑制或促进胆囊癌（GBC）患者癌症相关基因的表达，并可能作为肿瘤抑制因子或癌基因发挥作用，从而为胆囊癌的诊断和治疗提供了一个有前景的工具。在本综述中，我们总结了失调的微小RNA表达在与胆囊癌相关的信号通路中的作用，并讨论了循环微小RNA在胆囊癌中的重要作用。因此，微小RNA可能作为胆囊癌的新型治疗靶点以及诊断或预后标志物。
相似文献
1
The role of microRNAs in gallbladder cancer.微小RNA在胆囊癌中的作用。
Mol Clin Oncol. 2016 Jul;5(1):7-13. doi: 10.3892/mco.2016.905. Epub 2016 May 11.
2
Genetic Factors and MicroRNAs in the Development of Gallbladder Cancer: The Prospective Clinical Targets.胆囊癌发生中的遗传因素与微小RNA：潜在的临床靶点
Curr Drug Targets. 2024;25(6):375-387. doi: 10.2174/0113894501182288240319074330.
3
The potential role of miRNAs in the pathogenesis of gallbladder cancer - A focus on signaling pathways interplay.微小RNA在胆囊癌发病机制中的潜在作用——聚焦信号通路的相互作用
Pathol Res Pract. 2023 Aug;248:154682. doi: 10.1016/j.prp.2023.154682. Epub 2023 Jul 10.
4
MicroRNA aberrations: An emerging field for gallbladder cancer management.微小RNA异常：胆囊癌治疗的一个新兴领域。
World J Gastroenterol. 2016 Feb 7;22(5):1787-99. doi: 10.3748/wjg.v22.i5.1787.
5
Overexpressed microRNA-136 works as a cancer suppressor in gallbladder cancer through suppression of JNK signaling pathway via inhibition of MAP2K4.过表达 microRNA-136 通过抑制 MAP2K4 抑制 JNK 信号通路在胆囊癌中作为抑癌基因发挥作用。
Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G670-G681. doi: 10.1152/ajpgi.00055.2019. Epub 2019 Aug 1.
6
Role of MicroRNAs in Hepatocellular Carcinoma.微小RNA在肝细胞癌中的作用
Hepat Mon. 2014 Aug 1;14(8):e18672. doi: 10.5812/hepatmon.18672. eCollection 2014 Aug.
7
The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer.微小RNA miR-33a通过与胆囊癌中的Twist结合来抑制白细胞介素-6诱导的肿瘤进展。
Oncotarget. 2016 Nov 29;7(48):78640-78652. doi: 10.18632/oncotarget.12693.
8
MicroRNA signatures in total peripheral blood of gallbladder cancer patients.胆囊癌患者外周血中的微小RNA特征
Tumour Biol. 2015 Sep;36(9):6985-90. doi: 10.1007/s13277-015-3412-4. Epub 2015 Apr 11.
9
miR-101 targeting ZFX suppresses tumor proliferation and metastasis by regulating the MAPK/Erk and Smad pathways in gallbladder carcinoma.靶向ZFX的miR-101通过调节胆囊癌中的MAPK/Erk和Smad信号通路抑制肿瘤增殖和转移。
Oncotarget. 2016 Apr 19;7(16):22339-54. doi: 10.18632/oncotarget.7970.
10
MicroRNA expression and its implications for diagnosis and therapy of gallbladder cancer.微小RNA表达及其在胆囊癌诊断和治疗中的意义。
Oncotarget. 2015 Jun 10;6(16):13914-21. doi: 10.18632/oncotarget.4227.
引用本文的文献
1
Micro-RNAs With Prognostic Significance in Gallbladder Cancer: A Systematic Review and Meta-Analysis.具有胆囊癌预后意义的微小RNA：一项系统评价和荟萃分析
Cureus. 2024 Mar 4;16(3):e55515. doi: 10.7759/cureus.55515. eCollection 2024 Mar.
2
Identification of genes associated with gall bladder cell carcinogenesis: Implications in targeted therapy of gall bladder cancer.与胆囊细胞癌变相关基因的鉴定：对胆囊癌靶向治疗的意义。
World J Gastrointest Oncol. 2023 Dec 15;15(12):2053-2063. doi: 10.4251/wjgo.v15.i12.2053.
3
Meta-analysis of transcriptomics data identifies potential biomarkers and their associated regulatory networks in gallbladder cancer.转录组学数据的荟萃分析确定了胆囊癌中的潜在生物标志物及其相关调控网络。
Gastroenterol Hepatol Bed Bench. 2022;15(4):311-325. doi: 10.22037/ghfbb.v15i4.2292.
4
Circulating miR-141 as a potential biomarker for diagnosis, prognosis and therapeutic targets in gallbladder cancer.循环 miR-141 作为胆囊癌诊断、预后和治疗靶点的潜在生物标志物。
Sci Rep. 2022 Jun 16;12(1):10072. doi: 10.1038/s41598-022-13430-8.
5
Liquid biopsy in cholangiocarcinoma: Current status and future perspectives.胆管癌的液体活检：现状与未来展望。
World J Gastrointest Oncol. 2021 May 15;13(5):332-350. doi: 10.4251/wjgo.v13.i5.332.
6
miR-146b Functions as an Oncogene in Oral Squamous Cell Carcinoma by Targeting HBP1.miR-146b 通过靶向 HBP1 在口腔鳞状细胞癌中发挥癌基因作用。
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820959404. doi: 10.1177/1533033820959404.
7
Overexpression of microRNA-205-5p exerts suppressive effects on stem cell drug resistance in gallbladder cancer by down-regulating PRKCE.微小 RNA-205-5p 的过表达通过下调 PRKCE 对胆囊癌细胞干细胞耐药性发挥抑制作用。
Biosci Rep. 2020 Sep 30;40(9). doi: 10.1042/BSR20194509.
8
A Systemic Review on the Regulatory Roles of miR-34a in Gastrointestinal Cancer.miR-34a在胃肠道癌中调控作用的系统评价
Onco Targets Ther. 2020 Apr 3;13:2855-2872. doi: 10.2147/OTT.S234549. eCollection 2020.
9
Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells.将 miR-200c 和 Nkx2.1 封装在非转移性和转移性肺癌细胞的核/线粒体转录调控网络中。
BMC Cancer. 2019 Feb 11;19(1):136. doi: 10.1186/s12885-019-5337-6.
10
Epithelial-to-mesenchymal transition in gallbladder cancer: from clinical evidence to cellular regulatory networks.胆囊癌中的上皮-间质转化：从临床证据到细胞调控网络
Cell Death Discov. 2017 Nov 27;3:17069. doi: 10.1038/cddiscovery.2017.69. eCollection 2017.
本文引用的文献
1
MicroRNA-21 regulates non-small cell lung cancer cell proliferation by affecting cell apoptosis via COX-19.微小RNA-21通过COX-19影响细胞凋亡来调节非小细胞肺癌细胞的增殖。
Int J Clin Exp Med. 2015 Jun 15;8(6):8835-41. eCollection 2015.
2
Circulating MicroRNA and Long Noncoding RNA as Biomarkers of Cardiovascular Diseases.循环微小RNA和长链非编码RNA作为心血管疾病的生物标志物
J Cell Physiol. 2016 Apr;231(4):751-5. doi: 10.1002/jcp.25174. Epub 2015 Sep 9.
3
MicroRNA Processing and Human Cancer.微小RNA加工与人类癌症
J Clin Med. 2015 Aug 21;4(8):1651-67. doi: 10.3390/jcm4081651.
4
MicroRNA-148a inhibits migration of breast cancer cells by targeting MMP-13.微小RNA-148a通过靶向基质金属蛋白酶-13抑制乳腺癌细胞的迁移。
Tumour Biol. 2016 Feb;37(2):1581-90. doi: 10.1007/s13277-015-3926-9. Epub 2015 Aug 23.
5
miR-132 upregulation promotes gastric cancer cell growth through suppression of FoxO1 translation.miR-132上调通过抑制FoxO1翻译促进胃癌细胞生长。
Tumour Biol. 2016 Dec;37:15551–15557. doi: 10.1007/s13277-015-3924-y. Epub 2015 Aug 23.
6
miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1.miR-125a-5p 通过靶向 BCL2、BCL2L12 和 MCL1 抑制结肠癌细胞增殖并诱导细胞凋亡。
Biomed Pharmacother. 2015 Oct;75:129-36. doi: 10.1016/j.biopha.2015.07.036. Epub 2015 Aug 19.
7
Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma.微小RNA-24、微小RNA-320a和微小RNA-423-5p的血浆水平是结直肠癌的潜在生物标志物。
J Exp Clin Cancer Res. 2015 Aug 22;34(1):86. doi: 10.1186/s13046-015-0198-6.
8
Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma.小干扰RNA/微小干扰RNA在肝细胞癌中的治疗潜力
World J Gastroenterol. 2015 Aug 14;21(30):8994-9001. doi: 10.3748/wjg.v21.i30.8994.
9
Evaluation of miR-27a, miR-181a, and miR-570 genetic variants with gallbladder cancer susceptibility and treatment outcome in a North Indian population.在北印度人群中评估miR-27a、miR-181a和miR-570基因变异与胆囊癌易感性及治疗结果的关系。
Mol Diagn Ther. 2015 Oct;19(5):317-27. doi: 10.1007/s40291-015-0159-y.
10
MicroRNA-21: Mechanisms of Oncogenesis and its Application in Diagnosis and Prognosis of Gastric Cancer.微小RNA-21：胃癌的致癌机制及其在胃癌诊断和预后中的应用
Arch Iran Med. 2015 Aug;18(8):524-36.
Zotero 插件