Yang Ganghua, Zhang Lei, Li Ruixiang, Wang Lin
Department of Geriatric Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Mol Clin Oncol. 2016 Jul;5(1):7-13. doi: 10.3892/mco.2016.905. Epub 2016 May 11.
MicroRNAs (also referred to as miRNAs or miRs) play a crucial role in post-transcriptional gene regulation and serve as negative gene regulators by controlling a variety of target genes and regulating diverse biological processes, such as cell proliferation, invasion, migration and apoptosis. Aberrant expression of miRNAs is associated with the development and progression of cancer. Recent studies have reported that miRNAs may repress or promote the expression of cancer-related genes via several different signaling pathways in gallbladder cancer (GBC) patients and may function as tumor suppressors or oncogenes, thus providing a promising tool for the diagnosis and therapeutics of GBCs. In this review, we summarize the role of dysregulawted miRNA expression in the signaling pathways implicated in GBC and discuss the significant role of circulating miRNAs in GBC. Therefore, miRNAs may serve as novel therapeutic targets as well as diagnostic or prognostic markers in GBC.
微小RNA（也称为miRNA或miR）在转录后基因调控中发挥关键作用，并通过控制多种靶基因和调节多种生物学过程（如细胞增殖、侵袭、迁移和凋亡）作为负性基因调节因子。微小RNA的异常表达与癌症的发生和发展相关。最近的研究报道，微小RNA可能通过几种不同的信号通路抑制或促进胆囊癌（GBC）患者癌症相关基因的表达，并可能作为肿瘤抑制因子或癌基因发挥作用，从而为胆囊癌的诊断和治疗提供了一个有前景的工具。在本综述中，我们总结了失调的微小RNA表达在与胆囊癌相关的信号通路中的作用，并讨论了循环微小RNA在胆囊癌中的重要作用。因此，微小RNA可能作为胆囊癌的新型治疗靶点以及诊断或预后标志物。
