Park B S, Kim J, Kim U H, Kim H
Department of Science Education, Dankook University, Seoul, Korea.
Lipids. 1989 Oct;24(10):854-8. doi: 10.1007/BF02535759.
Previous studies on alpha-lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin. It was found that inclusion of phosphatidylcholine in the vesicles results in a depression of fusion. This depression of fusion appears to be caused by a reduction in the amount of irreversibly bound alpha-lactalbumin to vesicles containing phosphatidylcholine. It is suggested that in this system fusion is dependent upon the extent by which a particular protein segment penetrates the bilayer.
先前关于α-乳白蛋白诱导磷脂酰丝氨酸/磷脂酰乙醇胺囊泡融合的研究扩展到由磷脂酰丝氨酸、磷脂酰乙醇胺、磷脂酰胆碱和心磷脂的各种组合构成的囊泡。研究发现，囊泡中包含磷脂酰胆碱会导致融合受到抑制。这种融合抑制似乎是由于不可逆结合到含有磷脂酰胆碱的囊泡上的α-乳白蛋白量减少所致。有人提出，在该系统中，融合取决于特定蛋白质片段穿透双层的程度。
