使用氨基酸正电子发射断层扫描（PET）和传统磁共振成像（MRI）监测脑肿瘤治疗。
The use of amino acid PET and conventional MRI for monitoring of brain tumor therapy.
作者信息
Galldiks Norbert, Law Ian, Pope Whitney B, Arbizu Javier, Langen Karl-Josef
机构信息
Dept. of Neurology, University of Cologne, Cologne, Germany; Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Jülich, Germany; Center of Integrated Oncology (CIO), Universities of Cologne and Bonn, Cologne, Germany.
Dept.of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
出版信息
Neuroimage Clin. 2016 Dec 18;13:386-394. doi: 10.1016/j.nicl.2016.12.020. eCollection 2017.
Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/or immunotherapy may be limited. Metabolic imaging using PET can provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations. This review article focuses predominantly on the amino acid PET tracers C-methyl-l-methionine (MET), -(2-[F]fluoroethyl)-l-tyrosine (FET) and 3,4-dihydroxy-6-[F]-fluoro-l-phenylalanine (FDOPA) and summarizes investigations regarding monitoring of brain tumor therapy.
脑肿瘤的常规诊断和治疗监测通常基于对比增强磁共振成像（MRI）。然而，传统MRI区分肿瘤组织与神经外科切除、放化疗、烷基化化疗、放射外科和/或免疫治疗后的治疗效果的能力可能有限。使用正电子发射断层扫描（PET）的代谢成像可以提供有关肿瘤代谢的相关额外信息，这有助于进行更准确的诊断，尤其是在临床情况不明确的情况下。这篇综述文章主要关注氨基酸PET示踪剂L-甲基蛋氨酸（MET）、O-(2-[F]氟乙基)-L-酪氨酸（FET）和3,4-二羟基-6-[F]-氟-L-苯丙氨酸（FDOPA），并总结了有关脑肿瘤治疗监测的研究。
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