Vinskaia N P, Voloshina E A, Kozin S V
Med Radiol (Mosk). 1989 Oct;34(10):61-5.
The therapeutic efficacy of a scheme of poly-radiomodification with metronidazole (MZ) administration was investigated in experiments on mice with Ehrlich carcinoma before local irradiation of tumors and with subsequent induced hyperglycemia (IH) depending on a MZ dose. For equally effective potentiation of the effect of radiation on a tumor during a combined use of MZ and postradiation IH a 4-fold lower dose of the drug was required as combined to MZ used alone. The combined effect of the modifiers was superadditive. The use of IH in this scheme not only potentiated skin radiation reactions on a tumor growth zone but also slightly weakened their expression.
在对艾氏癌小鼠进行的实验中，研究了在肿瘤局部照射前及随后诱导高血糖（IH）情况下，给予甲硝唑（MZ）进行多放射修饰方案的治疗效果，该效果取决于MZ剂量。在联合使用MZ和放射后IH时，为使辐射对肿瘤的作用得到同等有效的增强，所需药物剂量比单独使用MZ时低4倍。这些修饰剂的联合作用具有超加性。在此方案中使用IH不仅增强了肿瘤生长区皮肤的辐射反应，而且还略微减弱了其表现。
