[Polyradiomodification. The efficacy of the postradiation use of hyperglycemia and hyperthermia in treating tumors of different sizes].

The paper is concerned with comparative assessment of the effectiveness of the separate and combined postradiation use of induced hyperglycemia (IH) and local hyperthermia (HT) with respect to tumor size in experiments on mice with transplantable Ehrlich carcinoma. The antitumor effect of these modalities was estimated by the criteria of the duration of tumor growth inhibition and cure of animals. The combined use of IH and HT significantly enhanced antitumor action of prior irradiation and resulted in improved therapeutic results for medium- and large-size tumors as compared to small ones. The authors discussed probable causes of enhancing the effectiveness of IH and HT with tumor growth, as a result of changes in pH, blood supply and other tumor characteristics.