Kozin S V, Voloshina E A, Vinskaia N P, Zaĭtsev A V
Med Radiol (Mosk). 1990 Jul;35(7):52-4.
The paper is concerned with comparative assessment of the effectiveness of the separate and combined postradiation use of induced hyperglycemia (IH) and local hyperthermia (HT) with respect to tumor size in experiments on mice with transplantable Ehrlich carcinoma. The antitumor effect of these modalities was estimated by the criteria of the duration of tumor growth inhibition and cure of animals. The combined use of IH and HT significantly enhanced antitumor action of prior irradiation and resulted in improved therapeutic results for medium- and large-size tumors as compared to small ones. The authors discussed probable causes of enhancing the effectiveness of IH and HT with tumor growth, as a result of changes in pH, blood supply and other tumor characteristics.
本文关注在可移植艾氏癌小鼠实验中，单独及联合使用辐射后诱导性高血糖（IH）和局部热疗（HT）对肿瘤大小的有效性进行比较评估。通过肿瘤生长抑制持续时间和动物治愈标准来评估这些方法的抗肿瘤效果。与小肿瘤相比，IH和HT联合使用显著增强了先前照射的抗肿瘤作用，并改善了中、大肿瘤的治疗效果。作者讨论了随着肿瘤生长，由于pH值、血液供应和其他肿瘤特征的变化，IH和HT有效性增强的可能原因。
