Delles Christian, Husi Holger
Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK.
School of Natural Sciences, University of Stirling, Stirling, UK.
Methods Mol Biol. 2017;1527:69-79. doi: 10.1007/978-1-4939-6625-7_6.
Systems biology is an approach to study all genes, gene transcripts, proteins, metabolites, and their interactions in specific cells, tissues, organs, or the whole organism. It is based on data derived from high-throughput analytical technologies and bioinformatics tools to analyze these data, and aims to understand the whole system rather than individual aspects of it. Systems biology can be applied to virtually all conditions and diseases and therefore also to hypertension and its underlying vascular disorders. Unlike other methods in this book there is no clear-cut protocol to explain a systems biology approach. We will instead outline some of the most important and common steps in the generation and analysis of systems biology data.
系统生物学是一种研究特定细胞、组织、器官或整个生物体中所有基因、基因转录本、蛋白质、代谢物及其相互作用的方法。它基于高通量分析技术和生物信息学工具所获得的数据来分析这些数据，旨在理解整个系统而非其个别方面。系统生物学几乎可应用于所有病症和疾病，因此也可应用于高血压及其潜在的血管疾病。与本书中的其他方法不同，目前尚无明确的方案来阐释系统生物学方法。相反，我们将概述系统生物学数据生成与分析过程中一些最重要且常见的步骤。
