De Mello Walmor C, Gerena Yamil
School of Medicine, Medical Sciences Campus UPR, 365067, San Juan, PR, 00936, USA.
Methods Mol Biol. 2017;1527:127-137. doi: 10.1007/978-1-4939-6625-7_10.
The molecular mechanisms related to the effect of angiotensin II, its level on cardiac tissues, as well as its overexpression represent an important aspect of cardiovascular pharmacology and pathology. Severe alterations of cardiac functions are induced by hypertension including activation of circulating and local cardiac renin angiotensin systems. In this chapter, we are providing the methods and materials necessary for further investigation of this important topic.
与血管紧张素II的作用、其在心脏组织中的水平及其过表达相关的分子机制是心血管药理学和病理学的一个重要方面。高血压会导致心脏功能的严重改变，包括循环和局部心脏肾素血管紧张素系统的激活。在本章中，我们提供了进一步研究这一重要课题所需的方法和材料。
