Searle G L, Feingold K R, Hsu F S, Clark O H, Gertz E W, Stanley W C
Veterans Administration Medical Center, San Francisco.
Metabolism. 1989 Nov;38(11):1120-3. doi: 10.1016/0026-0495(89)90050-4.
The extent to which lactate infusion may inhibit endogenous lactate production, though previously considered, has never been critically assessed. To examine this proposition, single injection tracer methodology (U-14C Lactate) has been used for the estimation of lactate kinetics in 12 human subjects under basal conditions and with the infusion of sodium lactate. The basal rate of lactate turnover was measured on a day before the study with lactate infusion, and averaged 63.7 + 5.5 mg/kg/h. Six of these individuals received a stable lactate infusion at an approximate rate of 160 mg/kg/h, while the remaining six individuals were infused at the approximate rate of 100 mg/kg/h. It has been found that stable lactate infused at rates approximating 160 mg/kg/h consistently produced a complete inhibition of endogenous lactate production. Infusion of lactate at 100 mg/kg/h caused a lesser and more variable inhibition of endogenous lactate production (12% to 64%). In conclusion, lactate infusion significantly inhibits endogenous lactate production.
尽管乳酸输注对内源性乳酸生成的抑制程度此前已被考虑过，但从未进行过严格评估。为了检验这一观点，采用单次注射示踪剂方法（U-14C乳酸）来估计12名人类受试者在基础状态下以及输注乳酸钠时的乳酸动力学。在进行乳酸输注研究的前一天测量乳酸周转的基础速率，平均为63.7 + 5.5毫克/千克/小时。其中6名个体以约160毫克/千克/小时的速率接受稳定的乳酸输注，而其余6名个体以约100毫克/千克/小时的速率输注。结果发现，以约160毫克/千克/小时的速率输注稳定的乳酸会持续完全抑制内源性乳酸生成。以100毫克/千克/小时的速率输注乳酸对内源性乳酸生成的抑制作用较小且变化较大（12%至64%）。总之，乳酸输注会显著抑制内源性乳酸生成。
