• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SCAP/SREBP信号通路：肝脂肪变性的介导因子

The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis.

作者信息

Moon Young Ah

机构信息

Department of Molecular Medicine, Inha University School of Medicine, Incheon, Korea.

出版信息

Endocrinol Metab (Seoul). 2017 Mar;32(1):6-10. doi: 10.3803/EnM.2017.32.1.6. Epub 2017 Jan 19.

DOI:10.3803/EnM.2017.32.1.6
PMID:28116873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5368123/
Abstract

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple accumulation of triglycerides in the hepatocytes to serious states accompanied by inflammation and fibrosis in the liver. De novo lipogenesis has been shown to be a significant factor in the development of hepatic steatosis in insulin-resistant states. Sterol regulatory element binding protein-1c (SREBP-1c) is the main transcription factor that mediates the activation of lipogenesis, and SREBP cleavage activating protein (SCAP) is required for the activation of SREBPs. Here, recent animal studies that suggest SCAP as a therapeutic target for hepatic steatosis and hypertriglyceridemia are discussed.

摘要

非酒精性脂肪性肝病（NAFLD）与胰岛素抵抗、肥胖和血脂异常密切相关。NAFLD涵盖了从肝细胞内甘油三酯单纯积聚到伴有肝脏炎症和纤维化的严重状态等广泛的情况。在胰岛素抵抗状态下，从头脂肪生成已被证明是肝脂肪变性发展的一个重要因素。固醇调节元件结合蛋白-1c（SREBP-1c）是介导脂肪生成激活的主要转录因子，而SREBP裂解激活蛋白（SCAP）是SREBPs激活所必需的。在此，讨论了近期提示SCAP作为肝脂肪变性和高甘油三酯血症治疗靶点的动物研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa24/5368123/96b571dcb665/enm-32-6-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa24/5368123/c535038bf638/enm-32-6-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa24/5368123/96b571dcb665/enm-32-6-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa24/5368123/c535038bf638/enm-32-6-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa24/5368123/96b571dcb665/enm-32-6-g002.jpg

相似文献

1
The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis.SCAP/SREBP信号通路：肝脂肪变性的介导因子
Endocrinol Metab (Seoul). 2017 Mar;32(1):6-10. doi: 10.3803/EnM.2017.32.1.6. Epub 2017 Jan 19.
2
The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.SCAP/SREBP 在肝脂肪变性中的脂质代谢中的中心调控作用。
Int J Mol Sci. 2024 Jan 16;25(2):1109. doi: 10.3390/ijms25021109.
3
Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c.肝脂肪变性：从头合成和转录因子 SREBP-1c 的作用。
Diabetes Obes Metab. 2010 Oct;12 Suppl 2:83-92. doi: 10.1111/j.1463-1326.2010.01275.x.
4
The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.Scap/SREBP 通路对于动物的糖尿病性脂肪肝和碳水化合物诱导的高甘油三酯血症的发展是必不可少的。
Cell Metab. 2012 Feb 8;15(2):240-6. doi: 10.1016/j.cmet.2011.12.017.
5
Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.促甲状腺素通过上调 SREBP-1c 活性增加肝内甘油三酯含量。
J Hepatol. 2014 Dec;61(6):1358-64. doi: 10.1016/j.jhep.2014.06.037. Epub 2014 Jul 10.
6
Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5'-UTR in a cellular model of hepatic steatosis.在肝脂肪变性细胞模型中，脂质蓄积通过促进hnRNP A1与SREBP-1a mRNA的5'-UTR结合，刺激其不依赖帽结构的翻译。
Biochim Biophys Acta. 2016 May;1861(5):471-81. doi: 10.1016/j.bbalip.2016.02.003. Epub 2016 Feb 8.
7
The Hexane Fraction of cyperus rotundus Prevents Non-Alcoholic Fatty Liver Disease Through the Inhibition of Liver X Receptor α-Mediated Activation of Sterol Regulatory Element Binding Protein-1c.香附的己烷馏分通过抑制肝脏X受体α介导的固醇调节元件结合蛋白-1c激活来预防非酒精性脂肪性肝病。
Am J Chin Med. 2015;43(3):477-94. doi: 10.1142/S0192415X15500305.
8
Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase.二十二碳六烯酸通过激活AMP活化蛋白激酶抑制固醇调节元件结合蛋白-1c（SREBP-1c）的蛋白水解加工。
Biochim Biophys Acta. 2015 Dec;1851(12):1521-9. doi: 10.1016/j.bbalip.2015.08.007. Epub 2015 Aug 29.
9
Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.抑制 SCAP/SREBP 加剧了小鼠非酒精性脂肪性肝炎的肝损伤和癌变。
J Clin Invest. 2022 Jun 1;132(11). doi: 10.1172/JCI151895.
10
Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation.斑马鱼急性酒精暴露后发生的肝脏脂肪变性需要固醇调节元件结合蛋白激活。
Hepatology. 2009 Feb;49(2):443-52. doi: 10.1002/hep.22667.

引用本文的文献

1
Strength training promotes attenuation of fatty liver while improving insulin resistance and inflammatory biomarkers in obese rats induced by high-fat diet.力量训练可促进高脂饮食诱导的肥胖大鼠脂肪肝的减轻，同时改善胰岛素抵抗和炎症生物标志物。
Braz J Med Biol Res. 2025 Aug 22;58:e14505. doi: 10.1590/1414-431X2025e14505. eCollection 2025.
2
Dietary Methionine Hydroxy Analog Regulates Hepatic Lipid Metabolism via SIRT1/AMPK Signaling Pathways in Largemouth Bass .日粮蛋氨酸羟基类似物通过大口黑鲈的SIRT1/AMPK信号通路调节肝脏脂质代谢
Biology (Basel). 2025 Feb 21;14(3):227. doi: 10.3390/biology14030227.
3
Ubiquitination and De-Ubiquitination in the Synthesis of Cow Milk Fat: Reality and Prospects.

本文引用的文献

1
Hepatic Steatosis and Insulin Resistance, But Not Steatohepatitis, Promote Atherogenic Dyslipidemia in NAFLD.肝脂肪变性和胰岛素抵抗而非脂肪性肝炎促进非酒精性脂肪性肝病中的致动脉粥样硬化血脂异常。
J Clin Endocrinol Metab. 2016 Feb;101(2):644-52. doi: 10.1210/jc.2015-3111. Epub 2015 Dec 16.
2
Relation of hepatic steatosis to atherogenic dyslipidemia.肝脂肪变性与动脉粥样硬化性血脂异常的关系。
Am J Cardiol. 2013 Nov 15;112(10):1599-604. doi: 10.1016/j.amjcard.2013.08.001. Epub 2013 Sep 5.
3
The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.
牛奶脂肪合成中的泛素化和去泛素化：现状与展望。
Molecules. 2024 Aug 29;29(17):4093. doi: 10.3390/molecules29174093.
4
Regeneration of Non-Alcoholic Fatty Liver Cells Using Chimeric FGF21/HGFR: A Novel Therapeutic Approach.利用嵌合 FGF21/HGFR 再生非酒精性脂肪肝细胞：一种新的治疗方法。
Int J Mol Sci. 2024 Mar 7;25(6):3092. doi: 10.3390/ijms25063092.
5
Robinetin Alleviates Metabolic Failure in Liver through Suppression of p300-CD38 Axis.刺槐素通过抑制p300-CD38轴减轻肝脏代谢功能衰竭。
Biomol Ther (Seoul). 2024 Mar 1;32(2):214-223. doi: 10.4062/biomolther.2023.061. Epub 2024 Feb 1.
6
SREBPs as the potential target for solving the polypharmacy dilemma.固醇调节元件结合蛋白作为解决多重用药困境的潜在靶点。
Front Physiol. 2024 Jan 10;14:1272540. doi: 10.3389/fphys.2023.1272540. eCollection 2023.
7
The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.SCAP/SREBP 在肝脂肪变性中的脂质代谢中的中心调控作用。
Int J Mol Sci. 2024 Jan 16;25(2):1109. doi: 10.3390/ijms25021109.
8
SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies.肝脏疾病中SREBP对脂质代谢的调控及治疗策略
Biomedicines. 2023 Dec 12;11(12):3280. doi: 10.3390/biomedicines11123280.
9
PM induced liver lipid metabolic disorders in C57BL/6J mice.PM 诱导 C57BL/6J 小鼠肝脏脂质代谢紊乱。
Front Endocrinol (Lausanne). 2023 Sep 14;14:1212291. doi: 10.3389/fendo.2023.1212291. eCollection 2023.
10
High Gamma-Aminobutyric Acid (GABA) Oolong Tea Alleviates High-Fat Diet-Induced Metabolic Disorders in Mice.高γ-氨基丁酸（GABA）乌龙茶减轻高脂饮食诱导的小鼠代谢紊乱。
ACS Omega. 2023 Sep 5;8(37):33997-34007. doi: 10.1021/acsomega.3c04874. eCollection 2023 Sep 19.
Scap/SREBP 通路对于动物的糖尿病性脂肪肝和碳水化合物诱导的高甘油三酯血症的发展是必不可少的。
Cell Metab. 2012 Feb 8;15(2):240-6. doi: 10.1016/j.cmet.2011.12.017.
4
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection.非酒精性脂肪性肝病与肝细胞癌：沉甸甸的关联。
Hepatology. 2010 May;51(5):1820-32. doi: 10.1002/hep.23594.
5
The epidemiology of nonalcoholic fatty liver disease: a global perspective.非酒精性脂肪性肝病的流行病学：全球视角
Semin Liver Dis. 2008 Nov;28(4):339-50. doi: 10.1055/s-0028-1091978. Epub 2008 Oct 27.
6
The epidemiology of nonalcoholic fatty liver disease in adults.成人非酒精性脂肪性肝病的流行病学
J Clin Gastroenterol. 2006 Mar;40 Suppl 1:S5-10. doi: 10.1097/01.mcg.0000168638.84840.ff.
7
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.非酒精性脂肪性肝病患者肝脏中储存并通过脂蛋白分泌的脂肪酸来源。
J Clin Invest. 2005 May;115(5):1343-51. doi: 10.1172/JCI23621.
8
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription.碳水化合物反应元件结合蛋白直接促进生脂酶基因转录。
Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15597-602. doi: 10.1073/pnas.0405238101. Epub 2004 Oct 20.
9
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.碳水化合物反应元件结合蛋白（ChREBP）的缺乏会降低脂肪生成以及糖酵解。
Proc Natl Acad Sci U S A. 2004 May 11;101(19):7281-6. doi: 10.1073/pnas.0401516101. Epub 2004 Apr 26.
10
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.肝脏过氧化物酶体增殖物激活受体γ参与肝脏脂肪变性、甘油三酯清除及身体脂肪量的调节。
J Biol Chem. 2003 Sep 5;278(36):34268-76. doi: 10.1074/jbc.M300043200. Epub 2003 Jun 11.