Chang Pearl W, Newman Thomas B, Maisels M Jeffrey
Seattle Children's Hospital, M/S FA.2.115, PO Box 5371, Seattle, WA 98145. United States.
Departments of Epidemiology & Biostatistics and Pediatrics, University of California, San Francisco, CA. United States.
Curr Pediatr Rev. 2017;13(3):181-187. doi: 10.2174/1573396313666170123151408.
Extreme hyperbilirubinemia and kernicterus, though rare, continue to occur despite the adoption of universal screening. Unless they are known to have glucose-6-phosphate dehydrogenase deficiency, infants who currently develop kernicterus in high resource countries are often otherwise healthy newborns discharged from the well-baby nursery. In this review, we highlight risk factors that increase the risk of a newborn ≥35 weeks gestational age developing severe hyperbilirubinemia, as well as the risk factors that increase the hyperbilirubinemic infant's risk of kernicterus.
尽管采用了普遍筛查，但极端高胆红素血症和核黄疸虽然罕见，但仍有发生。在资源丰富的国家，目前发生核黄疸的婴儿，除了已知患有葡萄糖-6-磷酸脱氢酶缺乏症外，通常是从健康婴儿托儿所出院的健康新生儿。在本综述中，我们重点介绍了增加孕龄≥35周新生儿发生严重高胆红素血症风险的危险因素，以及增加高胆红素血症婴儿发生核黄疸风险的危险因素。
