Yahya S, Heyes G, Nightingale P, Lamin S, Chavda S, Geh I, Spooner D, Cruickshank G, Sanghera P
Hall-Edwards Radiotherapy Research Group, Queen Elizabeth Hospital, Birmingham, United Kingdom.
Wolfson Computer Laboratory, University Hospitals Birmingham, NHS Foundation Trust, United Kingdom.
J Clin Neurosci. 2017 Apr;38:91-95. doi: 10.1016/j.jocn.2016.12.015. Epub 2017 Jan 21.
Arteriovenous malformations (AVMs) are the leading causing of intra-cerebral haemorrhage. Stereotactic radiosurgery (SRS) is an established treatment for arteriovenous malformations (AVM) and commonly delivered using Gamma Knife within dedicated radiosurgery units. Linear accelerator (LINAC) SRS is increasingly available however debate remains over whether it offers an equivalent outcome. The aim of this project is to evaluate the outcomes using LINAC SRS for AVMs used within a UK neurosciences unit and review the literature to aid decision making across various SRS platforms. Results have shown comparability across platforms and strongly supports that an adapted LINAC based SRS facility within a dynamic regional neuro-oncology department delivers similar outcomes (in terms of obliteration and toxicity) to any other dedicated radio-surgical platform. Locally available facilities can facilitate discussion between options however throughput will inevitably be lower than centrally based dedicated national radiosurgery units.
动静脉畸形(AVM)是脑内出血的主要原因。立体定向放射外科(SRS)是治疗动静脉畸形(AVM)的既定方法,通常在专用的放射外科设备中使用伽玛刀进行。直线加速器(LINAC)SRS越来越普及,但对于它是否能提供相同的治疗效果仍存在争议。本项目的目的是评估在英国神经科学单位使用LINAC SRS治疗AVM的效果,并回顾文献以辅助在各种SRS平台上进行决策。结果表明各平台之间具有可比性,并有力地支持了在动态区域神经肿瘤学部门内基于LINAC的适应性SRS设备能产生与任何其他专用放射外科平台相似的治疗效果(在闭塞和毒性方面)。当地可用的设备可以促进不同选择之间的讨论,然而其治疗量将不可避免地低于基于国家中心的专用放射外科单位。