Parfenov S B, Ozeretskovskaia N N, Pomigalov A Iu, Chistiakova I V
Med Parazitol (Mosk). 1989 Jul-Aug(4):72-5.
Studies of the time course of the immune status characteristics after praziquantel treatment and of the nature of its side-effects on various groups of opisthorchiasis patients in the focus established significant differences in their immune response to specific treatment. The lack of alterations in the T- and B-immunity systems in aboriginal population of the focus may suggest its tolerance to helminthic antigens. The trend towards cellular immunity stimulation and a significant increase in the levels of circulating immune complexes and specific antibodies in the serum were observed in aboriginal population of the focus. The comers showed significant initial alterations of the immunity status before treatment, pointing to their sensitization to parasitic antigens. Suppression of the infection normalizes several cellular and humoral immunity characteristics--the number of T-helpers, T-lymphocytes, B-lymphocytes, Th/Tc indices, T-lymphocyte functional activity, thus eliminating immune depression. The increased IgG, CIC and specific antibody levels significantly exceeding the normal level, occurrence or enhancement of allergic reactions point to the necessity of performing a desensitizing therapy and using effective cholagogic drugs in the multimodality treatment to rapidly eliminate the parasitic antigen.
对吡喹酮治疗后免疫状态特征的时间进程以及在疫源地对各类华支睾吸虫病患者的副作用性质进行的研究表明，他们对特定治疗的免疫反应存在显著差异。疫源地原住民群体中T和B免疫系统缺乏变化，这可能表明其对蠕虫抗原具有耐受性。在疫源地原住民群体中观察到细胞免疫刺激趋势以及血清中循环免疫复合物和特异性抗体水平显著升高。患者在治疗前免疫状态有明显的初始变化，表明他们对寄生虫抗原有致敏作用。感染得到抑制可使一些细胞和体液免疫特征正常化——T辅助细胞、T淋巴细胞、B淋巴细胞的数量、Th/Tc指数、T淋巴细胞功能活性，从而消除免疫抑制。IgG、CIC和特异性抗体水平升高，显著超过正常水平，过敏反应的出现或加重表明在多模式治疗中进行脱敏治疗和使用有效的利胆药物以迅速消除寄生虫抗原的必要性。
