心源性栓塞性卒中中炎症和内皮功能障碍的血液标志物：系统评价和荟萃分析。
Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis.
作者信息
Piccardi Benedetta, Giralt Dolors, Bustamante Alejandro, Llombart Victor, García-Berrocoso Teresa, Inzitari Domenico, Montaner Joan
机构信息
a Neuroscience Section, Department of Neurofarba , University of Florence , Florence , Italy.
b Neurovascular Research Laboratory , Vall d'Hebron University Hospital Research Institute (VHIR), Universitat Autònoma de Barcelona , Barcelona , Spain.
出版信息
Biomarkers. 2017 May-Jun;22(3-4):200-209. doi: 10.1080/1354750X.2017.1286689. Epub 2017 Feb 14.
CONTEXT
Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes.
OBJECTIVE
To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes.
METHODS
We systematically reviewed the literature (sources: MEDLINE, web-based register http://stroke-biomarkers.com , reference lists) with quality assessment and meta-analysis of selected articles.
RESULTS
The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001) Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke.
背景
包括炎症和内皮功能障碍在内的多种过程与心源性栓塞（CE）性卒中的发病机制有关。
目的
回顾相关证据并研究免疫炎症生物标志物与CE性卒中及其他卒中亚型之间的关联。
方法
我们系统地回顾了文献（来源：医学文献数据库、基于网络的注册库http://stroke-biomarkers.com 、参考文献列表），并对所选文章进行了质量评估和荟萃分析。
结果
与其他卒中亚型相比，C反应蛋白（CRP）与CE性卒中之间的关联最为一致（标准化均数差0.223（0.116，0.343）；p<0.001）。结论：我们的研究结果证实了所选炎症生物标志物与CE性卒中之间可能存在关联。
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