Möhrmann C, Glogner P, Caesar R
Med Klin (Munich). 1989 Sep 15;84(9):434-8.
All colon biopsy specimens of 28 months collected in an institute of pathology, providing a region of 660,000 inhabitants were reviewed for thickening of the subepithelial layer above the normal range of 7 mu. 16 cases were found, eleven of them with mild, uncharacteristic symptoms, eight even without diarrhea. Of the five cases with collagen layers above 10 mu, three suffered from intestinal diseases (unspecific protocolitis, active ulcerative colitis and malabsorption after ileum resection); two showed chronic diarrhea as symptoms of collagenous colitis. We conclude, that a subepithelial collagen layer is without any significance. Above 10 mu, two forms can be postulated: a reactive one, following chronic intestinal diseases and the idiopathic collagenous colitis syndrome of unknown etiology and pathogenesis. The presence of 185 cases is assumed in Western Germany, five of them already published.
对某病理学研究所收集的、来自66万居民地区的28个月内的所有结肠活检标本进行了检查，以查看上皮下层增厚是否超过正常范围7微米。发现了16例，其中11例有轻微的、不典型症状，8例甚至没有腹泻症状。在5例胶原层厚度超过10微米的病例中，3例患有肠道疾病（非特异性肠炎、活动性溃疡性结肠炎和回肠切除术后吸收不良）；2例表现为慢性腹泻，为胶原性结肠炎的症状。我们得出结论，上皮下胶原层没有任何意义。超过10微米时，可以假定有两种形式：一种是反应性的，继发于慢性肠道疾病；另一种是病因和发病机制不明的特发性胶原性结肠炎综合征。据推测，在西德有185例这种情况，其中5例已发表。
