Güller R
Gastroenterologische Praxis, Wettingen.
Schweiz Rundsch Med Prax. 1990 Jun 26;79(26):841-3.
The features of collagenous colitis are briefly summarized on the basis of 24 own patients and a review of the literature. Collagenous colitis is a rare diarrheal disease first described in 1976. The hallmark of this syndrome consists in a thickened layer of subepithelial collagen in the entire colon. Clinically patients present with longstanding, watery diarrhea. Laboratory tests, radiology and colonoscopy are all normal. Therefore the diagnosis is only established, if an alert colonoscopist takes biopsies out of an endoscopically normal appearing mucosa. There is no specific treatment, but patients usually respond to symptomatic therapy with antidiarrheal drugs. Microscopic colitis may represent an early stage of collagenous colitis.
基于24例自身患者及文献综述，对胶原性结肠炎的特征进行简要总结。胶原性结肠炎是一种罕见的腹泻性疾病，于1976年首次被描述。该综合征的标志是整个结肠上皮下胶原层增厚。临床上患者表现为长期水样腹泻。实验室检查、放射学检查及结肠镜检查均正常。因此，只有当警觉的结肠镜检查医生从内镜下外观正常的黏膜取活检时，才能确立诊断。目前尚无特异性治疗方法，但患者通常对抗腹泻药物的对症治疗有反应。显微镜下结肠炎可能是胶原性结肠炎的早期阶段。
