Mallappallil Mary, Sabu Jacob, Friedman Eli A, Salifu Moro
Department of Internal Medicine, State University of New York at Downstate, Brooklyn, New York, NY 11203, USA.
Int J Mol Sci. 2017 Jan 22;18(1):223. doi: 10.3390/ijms18010223.
Evidence suggests a link between opioid use and kidney disease. This review summarizes the known renal manifestations of opioid use including its role in acute and chronic kidney injury. Both the direct and indirect effects of the drug, and the context which leads to the development of renal failure, are explored. While commonly used safely for pain control and anesthesia in those with kidney disease, the concerns with respect to side effects and toxicity of opioids are addressed. This is especially relevant with the worldwide increase in the use of opioids for medical and recreational use.
有证据表明阿片类药物的使用与肾脏疾病之间存在联系。本综述总结了阿片类药物使用已知的肾脏表现，包括其在急性和慢性肾损伤中的作用。探讨了该药物的直接和间接影响，以及导致肾衰竭发生的背景情况。虽然阿片类药物通常在肾病患者中安全用于疼痛控制和麻醉，但也讨论了对其副作用和毒性的担忧。这在全球范围内阿片类药物用于医疗和娱乐用途的使用增加的情况下尤为重要。
