Assistant Professor of Medicine, State University of New York at Downstate, Brooklyn, NY; Director of Service Nephrology, Kings County Hospital Center, Health and Hospitals Corporation, Brooklyn, NY.
Clinical Instructor of Medicine, State University of New York at Downstate, Brooklyn, NY; Renal Fellow, Kings County Hospital Center, Health and Hospitals Corporation, Brooklyn, NY.
Semin Nephrol. 2021 Jan;41(1):11-18. doi: 10.1016/j.semnephrol.2021.02.002.
Opioid use and misuse in the United States has been at epidemic proportions and is predicted to increase further in the setting of the Coronavirus disease 19 pandemic. Acute kidney injury is a condition associated with significant morbidity and increased mortality. We review the literature on the effect of opioids on kidney function and critically examine the association between opioid use and acute kidney injury and identify at-risk populations in whom opioids should be used with caution. We also discuss the role of biomarkers in elucidating this condition and propose preventive measures, novel therapeutic options, and research directions.
在美国，阿片类药物的使用和滥用已经达到了流行的程度，并预计在 2019 冠状病毒病大流行的背景下进一步增加。急性肾损伤是一种与显著发病率和死亡率增加相关的疾病。我们回顾了关于阿片类药物对肾功能影响的文献，并对阿片类药物使用与急性肾损伤之间的关联进行了批判性的审查，确定了应谨慎使用阿片类药物的高危人群。我们还讨论了生物标志物在阐明这种情况中的作用，并提出了预防措施、新的治疗选择和研究方向。
