Ahmadian Mehdi, Dabidi Roshan Valiollah, Ashourpore Eadeh
a Department of Physical Education and Sport Science , Aliabad Katoul Branch, Islamic Azad University , Aliabad Katoul , Iran.
b Department of Sport Physiology , College of Physical Education and Sport Sciences, University of Mazandaran , Mazandaran , Iran.
J Diet Suppl. 2017 Jul 4;14(4):422-432. doi: 10.1080/19390211.2016.1267059. Epub 2017 Jan 24.
Taurine is an amino acid found abundantly in the heart in very high concentrations. It is assumed that taurine contributes to several physiological functions of mammalian cells, such as osmoregulation, anti-inflammation, membrane stabilization, ion transport modulation, and regulation of oxidative stress and mitochondrial protein synthesis. The objective of the current study was to evaluate the effectiveness of taurine supplementation on functional capacity, myocardial oxygen consumption, and electrical activity in patients with heart failure.
In a double-blind and randomly designed study, 16 patients with heart failure were assigned to two groups: taurine (TG, n = 8) and placebo (PG, n = 8). TG received 500-mg taurine supplementation three times per day for two weeks.
Significant decrease in the values of Q-T segments (p < 0.01) and significant increase in the values of P-R segments (p < 0.01) were detected following exercise post-supplementation in TG rather than in PG. Significantly higher values of taurine concentration, T wave, Q-T segment, physical capacities, and lower values of cardiovascular capacities were detected post-supplementation in TG as compared with PG (all p values <0.01).
Taurine significantly enhanced the physical function and significantly reduced the cardiovascular function parameters following exercise. Our results also suggest that the short-term taurine supplementation is an effective strategy for improving some selected hemodynamic parameters in heart failure patients. Together, these findings support the view that taurine improves cardiac function and functional capacity in patients with heart failure. This idea warrants further study.
牛磺酸是一种在心脏中大量存在的氨基酸，浓度非常高。据推测，牛磺酸有助于哺乳动物细胞的多种生理功能，如渗透调节、抗炎、膜稳定、离子转运调节以及氧化应激和线粒体蛋白质合成的调节。本研究的目的是评估补充牛磺酸对心力衰竭患者功能能力、心肌耗氧量和电活动的有效性。
在一项双盲随机设计的研究中，16名心力衰竭患者被分为两组：牛磺酸组（TG，n = 8）和安慰剂组（PG，n = 8）。TG组每天三次补充500毫克牛磺酸，持续两周。
补充后运动时，TG组而非PG组检测到Q-T段值显著降低（p < 0.01），P-R段值显著升高（p < 0.01）。与PG组相比，补充后TG组牛磺酸浓度、T波、Q-T段、身体能力的值显著更高，心血管能力的值更低（所有p值<0.01）。
牛磺酸显著增强了运动后的身体功能，并显著降低了心血管功能参数。我们的结果还表明，短期补充牛磺酸是改善心力衰竭患者某些选定血流动力学参数的有效策略。总之，这些发现支持了牛磺酸可改善心力衰竭患者心脏功能和功能能力的观点。这一观点值得进一步研究。
