Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?
作者信息
Daugherty Alan, Chen Zheying, Sawada Hisashi, Rateri Debra L, Sheppard Mary B
机构信息
Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY
Department of Physiology, University of Kentucky, Lexington, KY.
出版信息
J Am Heart Assoc. 2017 Jan 24;6(1):e005221. doi: 10.1161/JAHA.116.005221.
Abstract
摘要
相似文献
1
Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?转化生长因子-β在胸主动脉瘤中的作用：有益、有害还是无关？
J Am Heart Assoc. 2017 Jan 24;6(1):e005221. doi: 10.1161/JAHA.116.005221.
2
Genetics of thoracic aortic aneurysm: at the crossroad of transforming growth factor-β signaling and vascular smooth muscle cell contractility.胸主动脉瘤的遗传学：在转化生长因子-β信号和血管平滑肌细胞收缩性的交叉路口。
Circ Res. 2013 Jul 19;113(3):327-40. doi: 10.1161/CIRCRESAHA.113.300675.
3
Familial thoracic aortic aneurysms.家族性胸主动脉瘤
Curr Opin Cardiol. 2014 Nov;29(6):492-8. doi: 10.1097/HCO.0000000000000114.
4
Genetic and Epigenetic Regulation of Aortic Aneurysms.主动脉瘤的遗传与表观遗传调控
Biomed Res Int. 2017;2017:7268521. doi: 10.1155/2017/7268521. Epub 2017 Jan 1.
5
Early surgical experience with Loeys-Dietz: a new syndrome of aggressive thoracic aortic aneurysm disease.洛伊斯-迪茨综合征的早期外科治疗经验：一种侵袭性胸主动脉瘤疾病的新综合征
Ann Thorac Surg. 2007 Feb;83(2):S757-63; discussion S785-90. doi: 10.1016/j.athoracsur.2006.10.091.
6
Genetics of the extracellular matrix in aortic aneurysmal diseases.细胞外基质在主动脉瘤疾病中的遗传学研究。
Matrix Biol. 2018 Oct;71-72:128-143. doi: 10.1016/j.matbio.2018.04.005. Epub 2018 Apr 12.
7
Transforming growth factor-β and abdominal aortic aneurysms.转化生长因子-β与腹主动脉瘤。
Cardiovasc Pathol. 2013 Mar-Apr;22(2):126-32. doi: 10.1016/j.carpath.2012.07.005. Epub 2012 Sep 6.
8
Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm.基质金属蛋白酶2在胸主动脉瘤发病机制中的不同作用
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):888-98. doi: 10.1161/ATVBAHA.114.305115. Epub 2015 Feb 5.
9
Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome.氯沙坦钾和多西环素联合治疗与单一药物治疗在马凡综合征胸主动脉瘤二级预防中的疗效比较。
J Thorac Cardiovasc Surg. 2010 Aug;140(2):305-312.e2. doi: 10.1016/j.jtcvs.2009.10.039. Epub 2010 Feb 26.
10
Thoracic aortic aneurysm syndrome in children.儿童胸主动脉瘤综合征
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2008:11-21. doi: 10.1053/j.pcsu.2008.01.005.
引用本文的文献
1
Identification of Genetic Variants Associated with Hereditary Thoracic Aortic Diseases (HTADs) Using Next Generation Sequencing (NGS) Technology and Genotype-Phenotype Correlations.使用下一代测序（NGS）技术和基因型-表型相关性鉴定与遗传性胸主动脉疾病（HTADs）相关的遗传变异。
Int J Mol Sci. 2024 Oct 17;25(20):11173. doi: 10.3390/ijms252011173.
2
SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm.SLC44A2 调节血管平滑肌细胞表型转换和主动脉瘤。
J Clin Invest. 2024 Jun 25;134(16):e173690. doi: 10.1172/JCI173690.
3
The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome.抗氧化剂/一氧化氮淬灭剂钴胺酰胺可预防马凡综合征小鼠模型中的主动脉疾病。
JACC Basic Transl Sci. 2023 Oct 4;9(1):46-62. doi: 10.1016/j.jacbts.2023.07.014. eCollection 2024 Jan.
4
Therapeutic potential of mesenchymal stem cells and their secreted extracellular vesicles in thoracic aortic aneurysm disease.间充质干细胞及其分泌的细胞外囊泡在胸主动脉瘤疾病中的治疗潜力
J Thorac Cardiovasc Surg. 2024 Jan;167(1):89-93.e1. doi: 10.1016/j.jtcvs.2023.03.033. Epub 2023 Apr 20.
5
Molecular Mechanisms in Genetic Aortopathy-Signaling Pathways and Potential Interventions.遗传性主动脉病的分子机制-信号通路与潜在干预措施。
Int J Mol Sci. 2023 Jan 16;24(2):1795. doi: 10.3390/ijms24021795.
6
Tracking an Elusive Killer: State of the Art of Molecular-Genetic Knowledge and Laboratory Role in Diagnosis and Risk Stratification of Thoracic Aortic Aneurysm and Dissection.追踪隐匿杀手：胸主动脉瘤和夹层的分子遗传学知识现状及实验室在诊断和风险分层中的作用
Diagnostics (Basel). 2022 Jul 22;12(8):1785. doi: 10.3390/diagnostics12081785.
7
Postnatal Smad3 Inactivation in Murine Smooth Muscle Cells Elicits a Temporally and Regionally Distinct Transcriptional Response.小鼠平滑肌细胞中产后Smad3失活引发时间和区域上不同的转录反应。
Front Cardiovasc Med. 2022 Apr 8;9:826495. doi: 10.3389/fcvm.2022.826495. eCollection 2022.
8
Inflammasome Targeted Therapy as Novel Treatment Option for Aortic Aneurysms and Dissections: A Systematic Review of the Preclinical Evidence.炎性小体靶向治疗作为主动脉瘤和夹层的新型治疗选择：临床前证据的系统评价
Front Cardiovasc Med. 2022 Jan 20;8:805150. doi: 10.3389/fcvm.2021.805150. eCollection 2021.
9
Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms.主动脉瘤中的血管平滑肌细胞：从遗传学角度到机制。
J Am Heart Assoc. 2021 Dec 21;10(24):e023601. doi: 10.1161/JAHA.121.023601. Epub 2021 Nov 19.
10
Oxidative Stress-Related Susceptibility to Aneurysm in Marfan's Syndrome.马凡综合征中与氧化应激相关的动脉瘤易感性。
Biomedicines. 2021 Sep 6;9(9):1171. doi: 10.3390/biomedicines9091171.
本文引用的文献
1
Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling.马凡综合征小鼠模型中的主动脉病变并非由转化生长因子β信号改变介导。
J Am Heart Assoc. 2017 Jan 24;6(1):e004968. doi: 10.1161/JAHA.116.004968.
2
TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions.转化生长因子-β中和作用增强了血管紧张素II诱导的胸腹部主动脉破裂和动脉瘤形成。
PLoS One. 2016 Apr 22;11(4):e0153811. doi: 10.1371/journal.pone.0153811. eCollection 2016.
3
Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.尽管细胞外基质特性受损，但药理增强的收缩性可保护转化生长因子-β信号传导中断的小鼠免受主动脉夹层的影响。
Arterioscler Thromb Vasc Biol. 2016 May;36(5):919-27. doi: 10.1161/ATVBAHA.116.307436. Epub 2016 Mar 17.
4
Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.LTBP-3对马凡综合征胸主动脉瘤贡献的遗传分析。
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14012-7. doi: 10.1073/pnas.1507652112. Epub 2015 Oct 22.
5
Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice.产后平滑肌细胞中II型转化生长因子-β受体的缺失导致小鼠严重主动脉病变。
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56. doi: 10.1161/ATVBAHA.115.306573. Epub 2015 Oct 22.
6
Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.转化生长因子-β信号在小鼠主动脉瘤进展过程中的双相作用提示了马凡综合征的联合治疗方案。
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22.
7
A healthy tension in translational research.转化研究中的健康张力。
J Clin Invest. 2014 Apr;124(4):1425-9. doi: 10.1172/JCI75840. Epub 2014 Apr 1.
8
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.Tgfbr2 缺失导致出生后平滑肌功能障碍，破坏主动脉壁内稳态。
J Clin Invest. 2014 Feb;124(2):755-67. doi: 10.1172/JCI69942. Epub 2014 Jan 9.
9
Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.血管紧张素 II 依赖性 TGF-β 信号通路参与了洛伊茨-迪茨综合征的血管发病机制。
J Clin Invest. 2014 Jan;124(1):448-60. doi: 10.1172/JCI69666. Epub 2013 Dec 20.
10
Molecular mechanisms of thoracic aortic dissection.胸主动脉夹层的分子机制。
J Surg Res. 2013 Oct;184(2):907-24. doi: 10.1016/j.jss.2013.06.007. Epub 2013 Jun 29.
Zotero 插件