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Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?

作者信息

Daugherty Alan, Chen Zheying, Sawada Hisashi, Rateri Debra L, Sheppard Mary B

机构信息

Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY

Department of Physiology, University of Kentucky, Lexington, KY.

出版信息

J Am Heart Assoc. 2017 Jan 24;6(1):e005221. doi: 10.1161/JAHA.116.005221.

DOI:10.1161/JAHA.116.005221
PMID:28119286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5523646/
Abstract
摘要

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本文引用的文献

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Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling.马凡综合征小鼠模型中的主动脉病变并非由转化生长因子β信号改变介导。
J Am Heart Assoc. 2017 Jan 24;6(1):e004968. doi: 10.1161/JAHA.116.004968.
2
TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions.转化生长因子-β中和作用增强了血管紧张素II诱导的胸腹部主动脉破裂和动脉瘤形成。
PLoS One. 2016 Apr 22;11(4):e0153811. doi: 10.1371/journal.pone.0153811. eCollection 2016.
3
Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.尽管细胞外基质特性受损，但药理增强的收缩性可保护转化生长因子-β信号传导中断的小鼠免受主动脉夹层的影响。
Arterioscler Thromb Vasc Biol. 2016 May;36(5):919-27. doi: 10.1161/ATVBAHA.116.307436. Epub 2016 Mar 17.
4
Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.LTBP-3对马凡综合征胸主动脉瘤贡献的遗传分析。
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14012-7. doi: 10.1073/pnas.1507652112. Epub 2015 Oct 22.
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Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice.产后平滑肌细胞中II型转化生长因子-β受体的缺失导致小鼠严重主动脉病变。
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56. doi: 10.1161/ATVBAHA.115.306573. Epub 2015 Oct 22.
6
Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.转化生长因子-β信号在小鼠主动脉瘤进展过程中的双相作用提示了马凡综合征的联合治疗方案。
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22.
7
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Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.Tgfbr2 缺失导致出生后平滑肌功能障碍，破坏主动脉壁内稳态。
J Clin Invest. 2014 Feb;124(2):755-67. doi: 10.1172/JCI69942. Epub 2014 Jan 9.
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Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.血管紧张素 II 依赖性 TGF-β 信号通路参与了洛伊茨-迪茨综合征的血管发病机制。
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Molecular mechanisms of thoracic aortic dissection.胸主动脉夹层的分子机制。
J Surg Res. 2013 Oct;184(2):907-24. doi: 10.1016/j.jss.2013.06.007. Epub 2013 Jun 29.