Huang Jia-Rong, Tan Guang-Mou, Li Yong, Shi Zhi
Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People's Republic of China (J.-R.H., Z.S.); Department of Head & Neck Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China (G.-M.T.); and Department of Gastrointestinal Surgery & General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China (Y.L.).
Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People's Republic of China (J.-R.H., Z.S.); Department of Head & Neck Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China (G.-M.T.); and Department of Gastrointestinal Surgery & General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China (Y.L.)
Mol Pharmacol. 2017 Sep;92(3):240-245. doi: 10.1124/mol.116.107730. Epub 2017 Jan 24.
Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and -catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases.
细胞周期蛋白依赖性激酶5和Abl酶底物1（Cables1）是一种衔接蛋白，可将细胞周期蛋白依赖性激酶（Cdks）与非受体酪氨酸激酶联系起来，并通过增强其Y15磷酸化来调节Cdks的活性。新出现的证据还表明，Cables1可以与例如p53家族蛋白、14-3-3和β-连环蛋白相互作用，这表明Cables1可能是调节细胞生长的信号枢纽。在多种癌症和其他疾病中都观察到了Cables1的异常表达。在本综述中，我们总结了Cables1的特征，并强调了Cables1调节癌症和其他疾病发展的分子机制。最后，我们讨论了在证明Cables1在癌症和其他疾病中的作用及潜在应用方面未来面临的挑战。
