Bitton Etty, Courey Claudine, Giancola Pamela, Diaconu Vasile, Wise Jack, Wittich Walter
École d'optométrie, Université de Montréal, Montreal, Quebec, Canada.
Private Practitioner, Montreal, Quebec, Canada.
Clin Exp Optom. 2017 Nov;100(6):583-589. doi: 10.1111/cxo.12507. Epub 2017 Jan 25.
LATISSE is marketed for the treatment of hypotrichosis (loss of eyelashes), using a prostamide analogue and preserved with benzalkonium chloride, which is an effective preservative; however, it also causes irritation to the ocular surface. LATISSE is applied to the lid margin; however, with the blink, some solution may fall onto the ocular surface. The objective of this study was to assess the effects of LATISSE on the ocular surface over two months.
Non-dry eye participants interested in eyelash lengthening were invited to a prospective uncontrolled, open-label clinical study using LATISSE for two months. Eyelash length, subjective symptoms, tear film stability, osmolarity, ocular redness and intraocular pressure were evaluated at baseline (T0) and at one (T1) and two months (T2).
Twenty-eight women (ages 18 to 29) entered the study. Fifteen completed the study with five who discontinued due to burning upon instillation and eight were lost to follow-up. Average eyelash length increased at each time (p < 0.001). Dryness, burning and grittiness remained low (less than 25/100) throughout the trial with dryness showing a significant change between T0 and T1 (p = 0.04), but not between T1 and T2 (p > 0.05). No difference (p > 0.05) was noted for the non-invasive break-up time, photochromametry or tear osmolarity. Intraocular pressure showed a decrease with time but translated to only a one to two mmHg change, which was not clinically relevant.
LATISSE increases eyelash length within a short time (less than two months). Patients seeking eyelash enhancement options should be educated as to the use, precautions and any secondary effects, including the potential for discomfort upon instillation.
Latisse用于治疗睫毛稀少（睫毛脱落），其使用一种前列腺素类似物，并以苯扎氯铵作为有效防腐剂进行保存；然而，它也会对眼表造成刺激。Latisse应用于睑缘；但眨眼时，一些溶液可能会落到眼表。本研究的目的是评估Latisse在两个月内对眼表的影响。
邀请对睫毛变长感兴趣的非干眼参与者参加一项前瞻性非对照、开放标签的临床研究，使用Latisse两个月。在基线（T0）、1个月（T1）和2个月（T2）时评估睫毛长度、主观症状、泪膜稳定性、渗透压、眼发红和眼压。
28名女性（年龄18至29岁）进入研究。15人完成了研究，5人因滴入时灼烧而停药，8人失访。每次测量时平均睫毛长度均增加（p<0.001）。在整个试验过程中，干涩、灼烧和磨砂感的发生率较低（低于25/100），干涩感在T0和T1之间有显著变化（p=0.04），但在T1和T2之间无显著变化（p>0.05）。非侵入性泪膜破裂时间、光色度测量或泪液渗透压无差异（p>0.05）。眼压随时间下降，但仅变化1至2 mmHg，在临床上无相关性。
Latisse可在短时间内（不到两个月）增加睫毛长度。应告知寻求睫毛增强方法的患者有关其使用方法、注意事项及任何副作用，包括滴入时可能出现的不适。
