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槐花提取物对BALB/c小鼠胶原诱导性关节炎的保护作用。

Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice.

作者信息

Han Hyoung-Min, Hong Su-Hyun, Park Heung-Sik, Jung Jae-Chul, Kim Jong-Sik, Lee Yong-Tae, Lee Eun-Woo, Choi Yung-Hyun, Kim Byung-Woo, Kim Cheol-Min, Kang Kyung-Hwa

机构信息

Department of Physiology, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.

Department of Biochemistry, College of Korean Medicine, Dongeui University, Busan 614-851, Republic of Korea.

出版信息

Exp Ther Med. 2017 Jan;13(1):146-154. doi: 10.3892/etm.2016.3929. Epub 2016 Nov 25.

DOI:10.3892/etm.2016.3929
PMID:28123483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5245053/
Abstract

(L.) is utilized in Korean medicine for the treatment of various inflammatory diseases. The aim of the present study was to explore the effects of Fructus sophorae extract (FSE) isolated from the dried ripe fruit of (L.) on the development of type II collagen-induced arthritis (CIA) in BALB/c mice. The CIA mice were orally administered FSE or saline daily for 2 weeks. The incidence and severity of disease and the inflammatory response in the serum and the joint tissues were assessed. Macroscopic and histological investigation indicated that FSE protected against CIA development. FSE was associated with a significant reduction in the levels of total immunoglobulin G2a and proinflammatory cytokines and mediators in the serum. In addition, FSE suppressed the gene expression levels of proinflammatory cytokines and mediators, the mediator of osteoclastic bone remodeling, the receptor activator of nuclear factor κ-B ligand and matrix metalloproteinases in the joint tissues. The present results suggest that FSE may protect against inflammation and bone damage, and would be a valuable candidate for further investigation as a novel anti-arthritic agent.

摘要

（L.）在韩医学中用于治疗各种炎症性疾病。本研究的目的是探讨从（L.）干燥成熟果实中分离得到的槐角提取物（FSE）对BALB/c小鼠II型胶原诱导性关节炎（CIA）发展的影响。将CIA小鼠每天口服给予FSE或生理盐水，持续2周。评估疾病的发病率和严重程度以及血清和关节组织中的炎症反应。宏观和组织学研究表明，FSE可预防CIA的发展。FSE与血清中总免疫球蛋白G2a以及促炎细胞因子和介质水平的显著降低有关。此外，FSE抑制了关节组织中促炎细胞因子和介质、破骨细胞骨重塑介质、核因子κ-B配体受体激活剂和基质金属蛋白酶的基因表达水平。目前的结果表明，FSE可能预防炎症和骨损伤，作为一种新型抗关节炎药物，将是进一步研究的有价值候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe9/5245053/8e893f701678/etm-13-01-0146-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe9/5245053/e3a3d824b4a1/etm-13-01-0146-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe9/5245053/218d084be3c6/etm-13-01-0146-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe9/5245053/8e893f701678/etm-13-01-0146-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe9/5245053/e3a3d824b4a1/etm-13-01-0146-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe9/5245053/218d084be3c6/etm-13-01-0146-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe9/5245053/8e893f701678/etm-13-01-0146-g04.jpg

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