Behl Tapan, Kotwani Anita
Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
J Pharm Pharmacol. 2017 Mar;69(3):223-235. doi: 10.1111/jphp.12683. Epub 2017 Jan 26.
To explore the various pharmacological actions and the molecular mechanisms behind them by which Chinese herbs tend to lower the risk of developing microvascular diabetic complications in retina and prevent its further progression.
Several Chinese herbs, indeed, elicit potent anti-inflammatory, antioxidant, anti-angiogenic, anti-apoptotic, peroxisome proliferator-activated receptor-gamma receptor agonistic, platelet-activating factor antagonistic, aldose reductase inhibitory and various other beneficial pharmacological activities, required to counteract the pathological conditions prevalent in retina during diabetes.
Chinese herbs can potentially be used for the treatment/prevention of diabetic retinopathy owing to the virtue of numerous properties by which they alleviate several hyperglycaemia-induced pathological occurrences in retina. This would provide a natural and safe therapy for diabetic retinopathy, which currently is clinically limited to destructive techniques like laser photocoagulation and vitrectomy.
探讨中药降低视网膜微血管糖尿病并发症发生风险并防止其进一步发展的各种药理作用及其背后的分子机制。
事实上，几种中药具有强大的抗炎、抗氧化、抗血管生成、抗凋亡、过氧化物酶体增殖物激活受体γ受体激动、血小板活化因子拮抗、醛糖还原酶抑制及其他多种有益药理活性，这些活性是对抗糖尿病期间视网膜普遍存在的病理状况所必需的。
由于中药具有多种特性，可减轻视网膜中几种高血糖诱导的病理情况，因此有可能用于治疗/预防糖尿病视网膜病变。这将为糖尿病视网膜病变提供一种天然且安全的治疗方法，而目前临床上该疾病的治疗局限于激光光凝和玻璃体切除术等破坏性技术。
