Appiotti A
Divisione di Neurologia, Ospedale Mauriziano, Umberto I, Torino.
Minerva Med. 1989 Oct;80(10):1073-7.
As the peripheral nerve often represents the first nervous structure compromised by exogenous toxic substances at clinical and subclinical level, a neurophysiological study was carried out on 20 addicts suffering from chronic opiate intoxication. Although none of the subjects presented signs of clinically active polyneuropathy at neurological examination, an electromyographic evaluation was carried out of motor and sensitive conduction rate in the upper and lower extremities with a study of H reflex so as to ascertain possible peripheral compromise in a subclinical phase. The same study was also carried out in a control group consisting of 20 subjects, homogeneous for sex and age. Analysis of the results obtained points to a slight but statistically significant reduction in two conduction parameters which would seem to point to slight trouble in the peripheral nerve.
由于外周神经在临床和亚临床水平上常是受外源性有毒物质损害的首个神经结构，因此对20名患有慢性阿片类药物中毒的成瘾者进行了神经生理学研究。尽管在神经学检查中，没有一名受试者表现出临床活动性多发性神经病的体征，但仍对上下肢的运动和感觉传导速度进行了肌电图评估，并研究了H反射，以确定亚临床阶段可能存在的外周损害。在一个由20名年龄和性别均相同的受试者组成的对照组中也进行了同样的研究。对所得结果的分析表明，两个传导参数略有但具有统计学意义的降低，这似乎表明外周神经存在轻微问题。
