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放射性骨坏死的成本分析

Cost analysis of osteoradionecrosis.

作者信息

Park L, Lilic N, Addison B, Patel R

机构信息

Department of Otolaryngology Head and Neck Surgery,North Shore Hospital,Auckland,New Zealand.

Department of Otolaryngology Head and Neck Surgery,Auckland City Hospital,New Zealand.

出版信息

J Laryngol Otol. 2017 Apr;131(4):303-308. doi: 10.1017/S0022215116009956. Epub 2017 Jan 26.

Abstract

OBJECTIVE

Osteoradionecrosis is a significant complication of head and neck cancer treatment, and its most severe form (grade III) necessitates radical surgery. This study aimed to compare the cost of free-flap reconstructive surgery for grade III osteoradionecrosis and similar non-osteoradionecrosis cases in order to assess the cost burden of osteoradionecrosis treatment.

METHODS

All patients who underwent free-flap reconstructive surgery for osteoradionecrosis between July 2004 and July 2010 at Auckland City Hospital (19 patients) were identified, and relevant data were collected retrospectively. These patients were matched in terms of age and sex with patients who underwent free-flap reconstructive surgery.

RESULTS

The treatment cost was 44 per cent higher in osteoradionecrosis patients when compared to non-osteoradionecrosis patients.

CONCLUSION

The significant financial burden on the health system, and the growing evidence for the effectiveness of pentoxifylline, tocopherol and clodronate, should prompt us to explore this alternative treatment further.

摘要

目的

放射性骨坏死是头颈癌治疗的一种严重并发症,其最严重形式(III级)需要进行根治性手术。本研究旨在比较III级放射性骨坏死患者与类似的非放射性骨坏死患者的游离皮瓣重建手术费用,以评估放射性骨坏死治疗的成本负担。

方法

确定2004年7月至2010年7月期间在奥克兰市医院接受游离皮瓣重建手术治疗放射性骨坏死的所有患者(19例),并回顾性收集相关数据。将这些患者与接受游离皮瓣重建手术的患者按年龄和性别进行匹配。

结果

与非放射性骨坏死患者相比,放射性骨坏死患者的治疗费用高出44%。

结论

卫生系统面临的巨大经济负担,以及己酮可可碱、生育酚和氯膦酸盐有效性的证据不断增加,应促使我们进一步探索这种替代治疗方法。

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