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股前外侧阔筋膜张肌皮瓣游离移植术:对抗放射性骨坏死的新武器。

Anterolateral Thigh Fascia Lata Rescue Flap: A New Weapon in the Battle Against Osteoradionecrosis.

机构信息

Facial Plastic and Microvascular Surgery, Cleveland Clinic, Cleveland, Ohio, U.S.A.

Head and Neck Surgery, University of California, Los Angeles, California, U.S.A.

出版信息

Laryngoscope. 2021 Dec;131(12):2688-2693. doi: 10.1002/lary.29709. Epub 2021 Aug 6.

Abstract

OBJECTIVES

To demonstrate that the anterolateral thigh fascia lata (ALTFL) rescue flap may be effectively used for management of osteoradionecrosis (ORN) in selected patients.

STUDY DESIGN

Retrospective case review.

METHODS

Retrospective chart review was performed on patients who underwent ALTFL free flap repair to various sites of ORN in the head and neck between 2011 and 2018. Inclusion criteria were patients with radiographic and clinical evidence of head and neck ORN who either failed previous hyperbaric oxygen (HBO) therapy or with extensive disease, which was unlikely to respond to conservative management.

RESULTS

Twenty-three patients with average age of 63 years (40-78) who underwent 24 ALTFL free flap procedures were reviewed. ORN sites were the mandible (n = 16), palatomaxilla (n = 4), skull base and cervical spine (n = 3), and calvarium (n = 2). Recipient vessels used were superficial temporal (n = 11), common facial (n = 10), and angular (n = 3). Average hospital stay was 3.0 (1-10) days. Prior HBO therapy was performed in 13 (57%) patients. There were four major complications: flap failure, recurrent mandibular infection resolved with IV antibiotic course, mandibular fracture with malunion requiring occlusal adjustment, and unresolved sequelae of ORN requiring fibular free flap. There were four minor complications: thigh hematoma, thigh seroma, and intraoral scar formation causing trismus (n = 2). The procedure was successful in 22 of 23 (95.7%) patients with radiographic arrest of ORN, resolution of symptoms, and elimination of antibiotic requirements.

CONCLUSION

The ALTFL rescue flap merits strong consideration in ORN management and appears to prevent progression to more extensive disease, which would require full segmental bone resection and reconstruction.

LEVEL OF EVIDENCE

4 Laryngoscope, 131:2688-2693, 2021.

摘要

目的

证明股前外侧阔筋膜(ALTFL)游离皮瓣可有效用于治疗特定患者的放射性骨坏死(ORN)。

研究设计

回顾性病例研究。

方法

对 2011 年至 2018 年间,因头颈部 ORN 而接受 ALTFL 游离皮瓣修复的患者进行回顾性图表审查。纳入标准为影像学和临床证据证实的头颈部 ORN 患者,要么先前高压氧(HBO)治疗失败,要么疾病广泛,不太可能对保守治疗有反应。

结果

共 23 例平均年龄 63 岁(40-78 岁)的患者接受了 24 次 ALTFL 游离皮瓣手术。ORN 部位为下颌骨(n=16)、上颌骨(n=4)、颅底和颈椎(n=3)、颅骨(n=2)。使用的受区血管为颞浅动脉(n=11)、面动脉(n=10)和角动脉(n=3)。平均住院时间为 3.0(1-10)天。13 例(57%)患者行 HBO 治疗。有 4 种主要并发症:皮瓣失败、下颌感染复发经静脉抗生素疗程治愈、下颌骨骨折伴愈合不良需咬合调整、ORN 未愈的后遗症需游离腓骨皮瓣。有 4 种轻微并发症:大腿血肿、大腿血清肿和口腔内瘢痕形成导致牙关紧闭(n=2)。23 例患者中,22 例(95.7%)影像学 ORN 停止进展,症状缓解,无需使用抗生素。

结论

ALTFL 游离皮瓣在 ORN 治疗中值得高度考虑,似乎可防止疾病进一步发展,从而避免需要进行更广泛的骨切除和重建。

证据等级

4 Laryngoscope, 131:2688-2693, 2021.

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